Three screening batteries to detect cognitive impairment in multiple sclerosis
Three screening batteries to detect cognitive impairment in multiple sclerosis
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DOI：
10.1191/1352458502ms832oa
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发表时间：
2002-10-01
影响因子：
5.8
通讯作者：
Gontkovsky, ST
中科院分区：
文献类型：
--
作者：
Aupperle, RL;Beatty, WW;Gontkovsky, ST
为了比较多发性硬化（MS）患者认知功能障碍的检测灵敏度和三种简短的神经心理学测试的给药时间，64例MS患者完成了多发性硬化神经心理学筛查组合（NPSBMS），认知功能障碍筛查检查（SEFCI）和神经心理状态评估重复组合（RBANS）。特定测试的失败定义为健康对照组的评分低于第5百分位数，并确定每个组合中至少一项或两项测试（共四项）失败的患者数量。SEFCI和NPSBMS都比RBANS识别出更多的受损患者，而RBANS并不比简易精神状态检查（MMSE）更敏感。结果是相似的，在一个和两个失败的测试标准，但有没有显着差异SEFCI和NPSBMS在任何失败的标准。SEFCI的平均给药时间为22.6分钟，而NPSBMS为31.7分钟（p < 0.001）。11名（17%）患者拒绝尝试起搏听觉序列加法测试（PASAT），这是NPSBMS的一个组成部分。对于单次筛选患者，SEFCI是首选，因为其给药时间短于NPSBMS。
To compare the sensitivities for detecting cognitive impairment in patients with multiple sclerosis (MS) and administration times of three brief batteries of neuropsychological tests, 64 patients with MS completed the Neuropsychological Screening Battery for Multiple Sclerosis (NPSBMS), the Screening Examination for Cognitive Impairment (SEFCI), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Failure on a particular test was defined as a score below the 5th percentile for healthy controls, and the number of patients who failed at least one or two tests (out of four) was determined for each battery. Both the SEFCI and the NPSBMS identified significantly more patients with impairment than the RBANS, which was no more sensitive than the Mini-Mental State Exam (MMSE). Results were similar at both the one- and two-failed-tests criteria, but there were no significant differences between the SEFCI and the NPSBMS at either failure criterion. Mean administration time was 22.6 min for the SEFCI compared to 31.7 min for the NPSBMS (p < 0.001). Eleven (17%) of the patients refused to attempt the Paced Auditory Serial Addition Test (PASAT), one component of the NPSBMS. For screening patients on a single occasion, the SEFCI is preferred because its administration time is shorter than the NPSBMS.