An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem
An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem
复制标题
钯(II)催化烯丙基法罗培南裂解法法罗培南钠有机溶液中残留钯的有效去除方法
DOI：
--
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Fener Chen
中科院分区：
文献类型：
--
作者：
Jian Huang;Xu;Shuang‐Xi Gu;Lei Zhao;Chen Wenxue;Fener Chen
描述了一种改进的钯（II）催化法罗培南2烯丙基裂解法罗培南钠1的方法。在用聚苯乙烯结合的2,4,6-三巯基-s-三嗪（聚苯乙烯结合的TMT）处理原油1后，开发了一种去除钯杂质的有效方法，使最终分离产品中的残留钯含量从1500 - 1600 ppm急剧下降到小于10 ppm。在10 kg规模上验证了钯（II）催化解理和除钯工艺是非常方便和高效的。
An improved palladium(II)-catalyzed cleavage of the allyl group in allyl faropenem 2 into faropenem sodium 1 is described. The development of an efficient method for the removal of palladium impurities from the crude product 1 upon treatment with polystyrene-bound 2,4,6-trimercapto-s-triazine (polystyrene-bound TMT) led to a drastic decrease of residual palladium level from 1500−1600 ppm to less than 10 ppm in the final isolated product. The palladium(II)-catalyzed cleavage and palladium removal process demonstrated on 10 kg scale are highly convenient and efficient.