Salivary Telomere Length and Lung Function in Adolescents Born Very Preterm: A Prospective Multicenter Study.
Salivary Telomere Length and Lung Function in Adolescents Born Very Preterm: A Prospective Multicenter Study.
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DOI：
10.1371/journal.pone.0136123
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
EPIPAGEADO study group
中科院分区：
文献类型：
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作者：
Hadchouel A;Marchand-Martin L;Franco-Montoya ML;Peaudecerf L;Ancel PY;Delacourt C;EPIPAGEADO study group
早产与一生中呼吸功能异常有关。这些长期后果背后的机制仍不清楚。端粒的缩短与许多疾病有关，例如慢性阻塞性肺病。我们的目的是寻找端粒长度和早产青少年肺功能之间的联系。在纵向EPIPAGE队列中测量了236名早产青少年和38名足月生青少年的肺功能和端粒长度。端粒长度和肺活量指数之间的关联在考虑研究人群中混杂因素的单变量和多变量模型中进行了检验。早产青少年的气流明显低于对照组;极早产组的第一秒用力呼气量比对照组低12%（p<0.001）。低出生体重、支气管肺发育不良和产后败血症与低气流值显著相关。性别是唯一与端粒长度显着相关的因素。在单变量和多变量分析中，极早产青少年组的端粒长度与用力呼气流速25-75相关（分别为p = 0.01和p = 0.02）。我们证实了极早产青少年人群中端粒长度和异常气流之间的关联。与围产期事件无明显关联。这表明其他相关因素，如持续的气道氧化应激导致持续性炎症和肺功能改变，最终增加对慢性阻塞性肺疾病的易感性。
Preterm birth is associated with abnormal respiratory functions throughout life. The mechanisms underlying these long-term consequences are still unclear. Shortening of telomeres was associated with many conditions, such as chronic obstructive pulmonary disease. We aimed to search for an association between telomere length and lung function in adolescents born preterm. Lung function and telomere length were measured in 236 adolescents born preterm and 38 born full-term from the longitudinal EPIPAGE cohort. Associations between telomere length and spirometric indices were tested in univariate and multivariate models accounting for confounding factors in the study population. Airflows were significantly lower in adolescents born preterm than controls; forced expiratory volume in one second was 12% lower in the extremely preterm born group than controls (p<0.001). Lower birth weight, bronchopulmonary dysplasia and postnatal sepsis were significantly associated with lower airflow values. Gender was the only factor that was significantly associated with telomere length. Telomere length correlated with forced expiratory flow 25–75 in the extremely preterm adolescent group in univariate and multivariate analyses (p = 0.01 and p = 0.02, respectively). We evidenced an association between telomere length and abnormal airflow in a population of adolescents born extremely preterm. There was no evident association with perinatal events. This suggests other involved factors, such as a continuing airway oxidative stress leading to persistent inflammation and altered lung function, ultimately increasing susceptibility to chronic obstructive pulmonary disease.