Oral Vitamin A, E and D Supplementation of Pre-Term Newborns either Breast-Fed or Formula-Fed: a 3-Month Longitudinal Study
Oral Vitamin A, E and D Supplementation of Pre-Term Newborns either Breast-Fed or Formula-Fed: a 3-Month Longitudinal Study
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母乳喂养或配方奶喂养的早产新生儿口服维生素 A、E 和 D 补充剂：为期 3 个月的纵向研究
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
E. Levy
中科院分区：
文献类型：
--
作者：
E. Delvin;B. Salle;O. Claris;G. Putet;J. Hascoet;L. Desnoulez;Sam Messai;E. Levy
背景：与儿童、青少年和成人维生素A和E状况的研究相反，早产儿的信息很少。在本研究中，我们检查了早产儿出生时的维生素A、D和E状况，并验证了在1个月和3个月时，母乳喂养或配方奶粉喂养是否会影响这些维生素的血浆浓度，同时补充Uvesterol ADEC。患者和方法：在这项前瞻性研究中，2组连续招募的母乳或配方奶粉喂养的早产儿每天接受3000 IU维生素A、5 IU维生素E和1000 IU维生素D。采用高效液相色谱法和分光光度法测定维生素A和E。25-羟维生素D，维生素D状态的替代标记物，通过放射免疫测定法测定，视黄醇结合蛋白浓度通过免疫比浊法测定。结果如下：出生时，配方奶粉喂养和母乳喂养的婴儿的维生素A（0.75 ± 0.20和0.64 ± 0.21 mmol/L，ns）、25-羟基维生素D（34.4 ± 25.6和47.5 ± 26.7 nmol/L，ns）和维生素E（9.5 ± 3.2和8.4 ± 3.3 μmol/L，ns）的血浆浓度相似。两组婴儿的维生素A和E以及视黄醇结合蛋白浓度均随时间稳步增加，但在3个月时未达到足月儿和幼儿的正常值。在3个月大时，25-羟基维生素D的浓度达到与足月婴儿中观察到的值相当的值。结论：维生素A和E以及视黄醇结合蛋白的血浆浓度在研究期间稳步增加，但未达到完全饱足值。在研究结束时，营养类型不影响血浆维生素浓度。
Background: In contrast to the studies of vitamin A and E status in children, adolescents and adults, information on preterm infants is scarce. In the present investigation we examined the vitamin A, D and E status of pre-term infants at birth, and verified whether, at 1 and 3 months, breast or formula feeding affected the plasma concentration of those vitamins while being supplemented with Uvesterol ADEC. Patients and Methods: In this prospective study, 2 groups of consecutively recruited preterm newborns fed either breast milk or formula received 3000 IU of vitamin A, 5 IU of vitamin E and 1000 IU of vitamin D daily. Vitamin A and E were measured by high performance liquid chromatography and spectrophotometry. 25-hydroxyvitamin D, a surrogate marker for vitamin D status, was measured by radioimmunoassay, and retinol binding-protein concentration was measured by immunonephelometry. Results: At birth, formula-fed and breast-milk fed infants had similar plasma concentrations of vitamin A (0.75 ± 0.20 and 0.64 ± 0.21 m mol/L, ns), 25-hydroxyvitamin D (34.4 ± 25.6 and 47.5 ± 26.7 nmol/L, ns) and vitamin E (9.5 ± 3.2 and 8.4 ± 3.3 μmol/L, ns). Vitamins A and E, and retinol binding-protein concentrations steadily increased with time in both groups of infants without attaining, at 3 months, values considered normal in term infants and in young children. At 3 months of age, concentrations of 25-hydroxyvitamin D reached values comparable to those observed in term infants. Conclusion: Plasma concentrations of vitamins A and E and of retinol binding-protein steadily increased during the the study without reaching full repletion values. At the conclusion of the study, the type of nutrition did not affect plasma vitamin concentrations.
早产儿和足月新生儿的血浆维生素 A 和视黄醇结合蛋白。
DOI：
10.1016/s0022-3476(81)80484-2
发表时间：
1981
期刊：
The Journal of pediatrics
影响因子：
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作者：
Shenai,JP;Chytil,F;Jhaveri,A;Stahlman,MT
通讯作者：
Stahlman,MT
补充类胡萝卜素可纠正囊性纤维化儿童增加的脂质过氧化作用。
DOI：
10.1093/ajcn/64.1.87
发表时间：
1996
期刊：
The American journal of clinical nutrition
影响因子：
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作者：
Lepage,G;Champagne,J;Ronco,N;Lamarre,A;Osberg,I;Sokol,RJ;Roy,CC
通讯作者：
Roy,CC
幼儿的瞳孔和视觉阈值作为人群维生素 A 状态的指标。
DOI：
10.1093/ajcn/61.4.1076
发表时间：
1995
期刊：
The American journal of clinical nutrition
影响因子：
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作者：
Congdon,N;Sommer,A;Severns,M;Humphrey,J;Friedman,D;Clement,L;Wu,LS;Natadisastra,G
通讯作者：
Natadisastra,G