RISK-FACTORS FOR VARICOSE DISEASE BEFORE AND DURING PREGNANCY
RISK-FACTORS FOR VARICOSE DISEASE BEFORE AND DURING PREGNANCY
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DOI：
10.1177/000331979304400504
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发表时间：
1993-05-01
期刊：
影响因子：
2.8
通讯作者：
FERRARI, A
中科院分区：
文献类型：
--
作者：
DINDELLI, M;PARAZZINI, F;FERRARI, A
利用对611名在妇产科诊所连续分娩的妇女（平均年龄30岁，范围15至47岁）进行的妊娠期静脉疾病调查的数据，分析了妊娠前和妊娠期间静脉曲张疾病的危险因素。1989年1月至4月，米兰的曼吉加利。总共有137名妇女（22%）在指数妊娠前报告了静脉曲张疾病。首次妊娠前静脉曲张疾病的相对危险度（RR）随年龄增加而增加，与29岁或以下的女性相比，30 ~ 34岁的女性为1.6，35岁或以上的女性为4.1（chi 2（1）趋势29.28，p < 0.001）。与初产妇相比，首次妊娠前报告足月妊娠的妇女静脉疾病的RR为1.2，报告两次或两次以上分娩的妇女的风险增加至3.8（chi 2（1），趋势25.28，p < 0.001）。静脉曲张疾病家族史与静脉疾病的RR为6.2相关（95%置信区间，CI，从4.1到9.6）。静脉曲张和超重之间没有关系。在474名在首次妊娠前未报告静脉疾病的妇女中，132名（28%）在首次妊娠期间发生静脉疾病。妊娠期发生静脉疾病的风险随年龄增加而增加，与24岁或以下的女性相比，35岁或以上的女性发生静脉疾病的风险为4.0，风险趋势具有统计学显著性（chi 2（1）趋势16.25，p < 0.001）。二次或多次生育与妊娠期静脉疾病的风险增加有关。与生育过一个或多个孩子的妇女相比，估计RR为2.0（95% CI 1.3至2.9）。妊娠期发生静脉疾病的女性比未发生静脉疾病的女性更常报告静脉曲张疾病家族史; RR估计值为5.8（95%CI为3.8 - 8.9）。
Risk factors for varicose disease before and during pregnancy have been analyzed by use of data from a survey on venous disease in pregnancy conducted in 611 women (mean age thirty years, range fifteen to forty-seven) who consecutively delivered at the Obstetric-Gynecologic Clinic ''L. Mangiagalli'' of Milan between January and April, 1989. In total, 137 women (22%) reported varicose disease before the index pregnancy. The relative risk (RR) of varicose disease before the index pregnancy increased with age, being, as compared with women aged twenty-nine years or less, 1.6 in those aged thirty to thirty-four and 4.1 in those aged thirty-five years or more (chi2(1) trend 29.28, p < 0.001). Compared with nulliparae, women reporting a full-term pregnancy before the index pregnancy had an RR of venous disease of 1.2, and the risk increased to 3.8 in women reporting two or more births (chi2(1), trend 25.28, p < 0.001). A family history of varicose disease was associated with an RR of venous disease of 6.2 (95% confidence interval, CI, from 4.1 to 9.6). No relationship emerged between varicose disease and overweight. Of the 474 women who did not report venous disease before the index pregnancy, 132 (28%) developed venous disease during the index pregnancy. The risk of developing venous disease in pregnancy increased with age, being, as compared with women aged twenty-four years or less, 4.0 in those aged thirty-five years or more, and the trend in risk was statistically Significant (chi2(1) trend 16.25, p < 0.001). To be secondiparae or more was associated with an increased risk of developing venous disease in pregnancy. Compared with primiparae, the estimated RR was 2.0 (95% CI 1.3 to 2.9) in women reported to have given birth to one child or more. Women who developed venous disease in pregnancy reported more frequently a family history of varicose disease than those who did not; the RR estimate was 5.8, (95% CI from 3.8 to 8.9).