The paradox of dicer in cancer.
The paradox of dicer in cancer.
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DOI：
10.1080/23723556.2016.1155006
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发表时间：
2016-05
影响因子：
2.1
通讯作者：
Deshmukh M
中科院分区：
文献类型：
--
作者：
Swahari V;Nakamura A;Deshmukh M
迪切尔在癌症方面已经有了很好的研究，然而，破译其在肿瘤发生中的确切功能仍然是一个挑战。虽然部分抑制或截断DICER基因促进了肿瘤的发生，但其完全缺失抑制了肿瘤的生长。在这里，我们在最近发现它在DNA损伤反应中的作用的背景下讨论这一DICER癌症难题。
Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage response.