Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma.
Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma.
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DOI：
10.1038/bjc.1998.245
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发表时间：
1998-05
影响因子：
8.8
通讯作者：
Orfanos, C E
中科院分区：
文献类型：
--
作者：
Krasagakis, K;Tholke, D;Farthmann, B;Eberle, J;Mansmann, U;Orfanos, C E
先前已报道在人黑色素瘤细胞系和肿瘤中过度表达转化生长因子β亚型（TGF-β 1、-β 2、-β 3）。本研究的目的是评估黑色素瘤患者TGF-β亚型的血浆水平。在播散性但非局部黑色素瘤患者中，TGF-β 1（4.2 x对照组，P = 0.0094）和TGF-β 2（1.5 x对照组，P = 0.012）水平显著升高，但TGF-β 3水平未升高。这些结果表明，在终末期黑色素瘤患者中存在TGF-β家族的潜在免疫抑制肽的体循环。
Overexpression of transforming growth factor-beta isoforms (TGF-beta1, -beta2, -beta3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta1 (4.2 x the controls, P = 0.0094) and of TGF-beta2 (1.5 x the controls, P = 0.012) but not of TGF-beta3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.