Biochemical validation of self-reported exposure to environmental tobacco smoke.
Biochemical validation of self-reported exposure to environmental tobacco smoke.
复制标题
自我报告的环境烟草烟雾暴露的生化验证。
DOI：
10.1016/s0013-9351(89)80027-1
复制
发表时间：
1989
影响因子：
8.3
通讯作者：
Sepkovic,DW
中科院分区：
文献类型：
--
作者：
Haley,NJ;Colosimo,SG;Axelrad,CM;Harris,R;Sepkovic,DW
对报告的暴露于环境烟草烟雾(ETS)的生物化学验证为调查被动吸入烟雾与呼吸系统疾病或肺癌的相关性的流行病学研究提供了可信度。在目前的研究中，对非吸烟者进行了一系列关于ETS暴露的问题的自我调查，并将自我报告的暴露强度与现场获得的尿样中的可替宁水平进行了比较。这项研究的目标人群是一群报告在家庭环境和/或工作场所接触的市政工人。当被问及是否在社交场合接触过ETS时，回答积极的男性和女性的尿可替宁水平都高于回答消极的人(P<；0.02)。在报告与吸烟者同居的男性和女性中，平均尿可替宁浓度都被发现升高。报告接触者的尿可替宁水平是否认接触者尿液可替宁水平的两倍以上。在家中接触ETS是导致男性和女性尿可替宁水平升高的最大因素。在仅在工作中接触的个人中，报告的接触程度与尿可替宁值的平均值很好地吻合。这些发现强调，用生物标记物确认接触状况是调查被动吸烟的流行病学研究的基本前提。
Biochemical validation of reported exposure to environmental tobacco smoke (ETS) lends credibility to epidemiological studies investigating the association of passive inhalation of smoke to respiratory disease or lung cancer. In the current study, a series of questions regarding ETS exposure was self-administered to nonsmokers and self-reported intensity of exposure was compared with cotinine levels in urine samples obtained on site. The target population of this study was a group of municipal workers who reported exposure in a domestic setting and/or in the workplace. When asked if they were exposed to ETS on social occasions, both males and females who responded positively had higher urinary cotinine levels (P< 0.02) than those who gave a negative response. Mean urinary cotinine concentrations were found to be elevated in both men and women who reported that they lived with a smoker. Cotinine levels in the urine of those reporting exposure were over twice as high as those in the urine of respondents who denied having been exposed. ETS exposure in the home was the greatest contributor to increased urinary cotinine levels in both men and women. Among individuals who were exposed at work only, the reported degree of exposure agreed well with the mean urinary cotinine values. Those findings emphasize that the validation of exposure status with a biomarker is an essential prerequisite for epidemiological studies investigating passive smoking.