CO <sub>2</sub> ‐Assisted Stereocontrolled Multi‐Component Coupling Reactions Promoted by Ni‐Catalytic System
CO <sub>2</sub> ‐Assisted Stereocontrolled Multi‐Component Coupling Reactions Promoted by Ni‐Catalytic System
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CO <sub>2</sub> -镍催化体系促进的立体控制多组分偶联反应
DOI：
10.1002/ajoc.202200232
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发表时间：
2022
影响因子：
2.7
通讯作者：
Kimura Masanari
中科院分区：
文献类型：
--
作者：
Mori Takamichi;Noba Nao;Munakata Miho;Kimura Masanari
Ni催化剂和pph3的结合促进了环氧乙烯、炔和二甲基锌在二氧化碳气氛下的三组分偶联反应，得到了具有良好立体选择性的2,5 -庚二烯醇。多组分偶联反应产物的立体化学是通过插入二氧化碳形成的氧环中间体控制的。
A combination of Ni‐catalyst and PPh3promotes the three‐component coupling reaction of vinyl epoxide, alkyne, and dimethylzinc under a carbon dioxide atmosphere to provide 2,5‐heptadienyl alcohols with excellentE‐stereoselectivity. The stereochemistry of the products from the multi‐component coupling reaction is controlled via an oxanickelacycle intermediate, which is formed by the insertion of carbon dioxide.