Specifying a Causal Role for Angular Gyrus in Autobiographical Memory.
Specifying a Causal Role for Angular Gyrus in Autobiographical Memory.
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DOI：
10.1523/jneurosci.1239-18.2018
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发表时间：
2018-12-05
期刊：
影响因子：
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通讯作者：
Simons JS
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文献类型：
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作者：
Bonnici HM;Cheke LG;Green DAE;FitzGerald THMB;Simons JS
最近相当多的证据表明，人类的角回功能障碍不会导致健忘症，但确实会损害情景记忆的许多方面。据报道，顶叶病变患者在自由回忆过去的自传体事件时表现出缺陷，但在回忆时可以记住事件的细节。在明显的矛盾，抑制性脑刺激针对健康志愿者的角回已被发现对自由回忆或线索回忆的单词对没有影响。本研究试图解决这种不一致的测试自由和线索回忆自传体记忆和词对记忆在相同的健康男性和女性人类参与者连续theta爆发刺激（cTBS）的角回和顶点控制位置。角回cTBS导致选择性减少自由回忆，但不提示回忆，自传体记忆，而自由和提示回忆的词对记忆不受影响。此外，参与者报告较少的自传体事件，从第一人称的角度来看，角回cTBS。越来越多的证据表明，负责情景回忆的大脑区域网络中的角回的功能是将自我中心框架内的记忆特征整合到第一人称视角表征中，从而实现对个人过去事件的记忆的主观体验。在寻求理解顶叶皮质角回区域在人类记忆中所起的作用时，解释神经影像学和神经心理学研究中经常相互矛盾的发现受到解剖学特异性和方法之间定位差异的阻碍。在本研究中，我们解决这些限制，使用连续θ爆发刺激在健康志愿者中，破坏角回和顶点控制区的功能。通过这种方法，我们在顶叶功能的两种相互竞争的理论之间进行判断，发现与角回在记忆中的注意力作用不一致的证据，而是支持将自我中心框架内的记忆特征整合到第一人称视角表征中，从而实现记忆的主观体验。
Considerable recent evidence indicates that angular gyrus dysfunction in humans does not result in amnesia, but does impair a number of aspects of episodic memory. Patients with parietal lobe lesions have been reported to exhibit a deficit when freely recalling autobiographical events from their pasts, but can remember details of the events when recall is cued by specific questions. In apparent contradiction, inhibitory brain stimulation targeting angular gyrus in healthy volunteers has been found to have no effect on free recall or cued recall of word pairs. The present study sought to resolve this inconsistency by testing free and cued recall of both autobiographical memories and word-pair memories in the same healthy male and female human participants following continuous theta burst stimulation (cTBS) of angular gyrus and a vertex control location. Angular gyrus cTBS resulted in a selective reduction in the free recall, but not cued recall, of autobiographical memories, whereas free and cued recall of word-pair memories were unaffected. Additionally, participants reported fewer autobiographical episodes as being experienced from a first-person perspective following angular gyrus cTBS. The findings add to a growing body of evidence that a function of angular gyrus within the network of brain regions responsible for episodic recollection is to integrate memory features within an egocentric framework into the kind of first-person perspective representation that enables the subjective experience of remembering events from our personal pasts. SIGNIFICANCE STATEMENT In seeking to understand the role played by the angular gyrus region of parietal cortex in human memory, interpreting the often conflicting findings from neuroimaging and neuropsychology studies has been hampered by differences in anatomical specificity and localization between methods. In the present study, we address these limitations using continuous theta burst stimulation in healthy volunteers to disrupt function of angular gyrus and a vertex control region. With this method, we adjudicate between two competing theories of parietal lobe function, finding evidence that is inconsistent with an attentional role for angular gyrus in memory, supporting instead an account in terms of integrating memory features within an egocentric framework into a first-person perspective representation that enables the subjective experience of remembering.