Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).
Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).
复制标题
DOI：
10.1146/annurev-cellbio-100814-125315
复制
发表时间：
2015
影响因子：
11.3
通讯作者：
Mlodzik M
中科院分区：
文献类型：
--
作者：
Yang Y;Mlodzik M
上皮细胞和间充质细胞平面细胞极性（PCP）的建立是发育和器官发生过程中一个重要的、进化上保守的过程。对果蝇和几种脊椎动物模式生物的分析提供了大量关于五氯苯酚调控的信息。通过果蝇的遗传学研究，最初发现了一条调控PCP的关键保守途径，即所谓的核心Wnt-Frizzled PCP（Fz/PCP）信号通路。在脊椎动物（最值得注意的是小鼠和斑马鱼）中进行的五氯苯酚研究已经确定了五氯苯酚信号传导中的新因素，并确定了需要五氯苯酚信号输入的细胞特征。这些研究已经将焦点转移到货车Gogh（旺）/Vangl基因在该分子系统中的作用。本文综述了Fz/Vangl/PCP核心通路的最新进展以及果蝇和脊椎动物PCP研究的最新进展。我们试图将这些现有的核心Fz/Vangl/PCP信令框架内。
The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a critical, evolutionarily conserved process during development and organogenesis. Analyses in Drosophila and several vertebrate model organisms have contributed a wealth of information on the regulation of PCP. A key conserved pathway regulating PCP, the so-called core Wnt-Frizzled PCP (Fz/PCP) signaling pathway, was initially identified through genetic studies of Drosophila. PCP studies in vertebrates, most notably mouse and zebrafish, have identified novel factors in PCP signaling and have also defined cellular features requiring PCP signaling input. These studies have shifted focus to the role of Van Gogh (Vang)/Vangl genes in this molecular system. This review focuses on new insights into the core Fz/Vangl/PCP pathway and recent advances in Drosophila and vertebrate PCP studies. We attempt to integrate these within the existing core Fz/Vangl/PCP signaling framework.