Brush cells fine-tune neurogenic inflammation in the airways.
Brush cells fine-tune neurogenic inflammation in the airways.
复制标题
刷状细胞微调气道中的神经源性炎症。
DOI：
10.1172/jci161439
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发表时间：
2022-07-01
影响因子：
15.9
通讯作者：
Bankova, Lora G.
中科院分区：
文献类型：
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作者：
Ye, Qihua;Bankova, Lora G.
呼吸道上皮细胞曾经被认为是一层简单的屏障，现在被认为是抗原感应和免疫反应启动的活性部位。大多数粘膜部位含有化学感觉上皮细胞，这是一种罕见的特化细胞，因其在感知和指导免疫反应交响乐方面的独特功能而获得认可。在这一期的JCI中，Hollenhorst，Nandigama等人。证明了气管化学感觉刷状细胞检测到苦味物质，包括致病性铜绿假单胞菌产生的群体感应分子(QSM)。作者使用了多种技术，包括刷状细胞的遗传缺失、刷状细胞信号的遗传操作、感觉神经元的缺失、活体成像和铜绿假单胞菌感染模型，以表明QSM增加了血管通透性和先天性免疫细胞进入气管。这些发现将细菌QSM的识别与呼吸道的先天性免疫反应联系起来，并对呼吸道炎症和感染病理具有翻译意义。
Airway epithelial cells, once considered a simple barrier layer, are now recognized as providing an active site for antigen sensing and immune response initiation. Most mucosal sites contain chemosensory epithelial cells, rare and specialized cells gaining recognition for their unique functions in sensing and directing the immune response symphony. In this issue of the JCI, Hollenhorst, Nandigama, et al. demonstrated that tracheal chemosensory brush cells detected bitter-tasting substances, including quorum-sensing molecules (QSMs) generated by pathogenic Pseudomonas aeruginosa. The authors used various techniques, including genetic deletion of brush cells, genetic manipulation of brush cell signaling, deletion of sensory neurons, in vivo imaging, and infection models with P. aeruginosa, to show that QSMs increased vascular permeability and innate immune cell influx into the trachea. These findings link the recognition of bacterial QSMs to the innate immune response in the airways, with translational implications for airway inflammation and infectious pathology.