Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces
Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces
复制标题
消除大鼠粪便中的各种多氯二苯并-对-二恶英和二苯并呋喃（PCDD 和 PCDF）
DOI：
10.1007/bf00334639
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发表时间：
2004
影响因子：
6.1
通讯作者：
D. Neubert
中科院分区：
文献类型：
--
作者：
K. Abraham;T. Wiesmüller;H. Brunner;R. Krowke;H. Hagenmaier;D. Neubert
将一种确定的多氯二苯并对二恶英和多氯二苯并呋喃（PCDDs和PCDFs）混合物（其组成特征与焚烧炉飞灰中的混合物相同）皮下注射给大鼠，并测量了通过粪便消除未改变的同系物的情况。1)施用的所有同系物均存在于粪便中。2)不同的同系物通过粪便的消除率差别很大。3)毒性最大的同系物2378-T4 CDD和12378-P5 CDD在第一周内以未代谢形式存在于粪便中，分别占给药剂量的4%和8%。因此，与相应的经口给药相比，胃肠外给药明显最大限度地减少了动物区的污染。4)对于氯化程度较高的多氯二苯并对二恶英和多氯二苯并呋喃，其消除率显然没有变化。发现1234678-H7 CDD的排泄率最高（高达给药剂量的30%）。5)未观察到2378取代或非2378取代异构体通过粪便消除原型物质的速率存在明显差异。
A defined mixture (of a composition characteristic of that present in incinerator fly ash) of polychlorinated dibenzo-p-dioxins and -furans (PCDDs and PCDFs) was subcutaneously administered to rats and the elimination of the unchanged congeners via faeces was measured. 1) All congeners administered could be found in faeces. 2) The rates of elimination via faeces were rather different for the different congeners. 3) The most toxic congeners, 2378-T4CDD and 12378-P5CDD, were present in unmetabolized form in faeces to < 4% and < 8% of the administered dose within the first week. Thus, parenteral administration clearly minimizes contamination of the animal quarters when compared with corresponding oral dosing. 4) The rate of unchanged elimination was apparently especially pronounced for the higher chlorinated PCDDs and PCDFs. The highest excretion rate was found for 1234678-H7CDD (up to 30% of administered dose). 5) No obvious differences were observed in the rates of elimination of the unchanged substances via faeces of the 2378-substituted or the non-2378-substituted isomers.