Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning
Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning
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DOI：
10.1523/jneurosci.4919-12.2014
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发表时间：
2014-04-23
影响因子：
5.3
通讯作者：
Svoboda, Karel
中科院分区：
文献类型：
--
作者：
Kuhlman, Sandra J.;O'Connor, Daniel H.;Svoboda, Karel
我们报告学习相关的结构可塑性在第1层的锥体神经元的分支在桶皮质，一个已知的网站的感觉运动整合。在小鼠学习主动的，须依赖的对象定位任务，第2/3层神经元显示出增强的脊柱生长在初始技能获取，之前和预测专家的表现。先前存在的棘被稳定，并形成新的持续棘。这些发现表明运动中枢和感觉皮层之间的连接的快速变化指导随后的感觉运动学习。
We report learning-related structural plasticity in layer 1 branches of pyramidal neurons in the barrel cortex, a known site of sensorimotor integration. In mice learning an active, whisker-dependent object localization task, layer 2/3 neurons showed enhanced spine growth during initial skill acquisition that both preceded and predicted expert performance. Preexisting spines were stabilized and new persistent spines were formed. These findings suggest rapid changes in connectivity between motor centers and sensory cortex guide subsequent sensorimotor learning.