Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration
Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration
复制标题
骨早衰降低了骨髓间充质干细胞对视网膜变性的治疗效果
DOI：
10.1016/j.bbrc.2020.07.007
复制
发表时间：
2020-10-15
影响因子：
3.1
通讯作者：
Yu, Xiao-Rui
中科院分区：
文献类型：
--
作者：
Deng, Chun-Lei;Hu, Cheng-Biao;Yu, Xiao-Rui
衰老与视网膜变性的发生密切相关。近年来的研究表明，骨髓间充质干细胞（BMMSCs）对视网膜变性有显著的治疗作用，而BMMSCs在骨老化时功能下降。衰老是否影响BMMSCs对视网膜变性的治疗仍不清楚。在这里，我们应用了先前建立的骨早衰动物模型，即加速衰老的小鼠6（SAMP 6）品系，并令人惊讶地发现SAMP 6小鼠在6个月大时表现出视网膜变性。此外，源自SAMP 6小鼠的BMMSC未能在体内预防MNU诱导的视网膜变性。正如预期的那样，与来自年龄匹配的加速衰老小鼠抗性1（SAMR 1）品系的BMMSC相比，来自SAMP 6小鼠的BMMSC表现出分化能力受损。此外，来自SAMR 1小鼠的BMMSC抵消了MNU诱导的视网膜变性，增加了视网膜存活标志N-myc下游调节基因2（NDRG 2）的表达。总之，这些发现表明，骨早衰症减少了BMMSC对视网膜变性的治疗效果。(C)2020年，任作家。爱思唯尔公司出版
Senescence is closely related to the occurrence of retinal degeneration. Recent studies have shown that bone marrow mesenchymal stem cells (BMMSCs) have significant therapeutic effects on retinal degeneration, While BMMSCs suffer from functional decline in bone aging. Whether senescence affects BMMSCs therapy on retinal degeneration remains unknown. Here, we applied the previously established bone progeria animal model, the senescence-accelerated mice-prone 6 (SAMP6) strain, and surprisingly discovered that SAMP6 mice demonstrated retinal degeneration at 6 months old. Furthermore, BMMSCs derived from SAMP6 mice failed to prevent MNU-induced retinal degeneration in vivo. As expected, BMMSCs from SAMP6 mice exhibited impairment in the differentiation capacities, compared to those from the age-matched senescence-accelerated mice-resistant 1 (SAMR1) strain. Moreover, BMMSCs from SAMR1 mice counteracted MNU-induced retinal degeneration, with increased expression of the retina survival hallmark, N-myc downstream regulated gene 2 (NDRG2). Taken together, these findings reveal that bone progeria diminished the therapeutic effects of BMMSC on retinal degeneration. (C) 2020 The Authors. Published by Elsevier Inc.