Discrimination of benign from malignant hepatic lesions based on their T2-relaxation times calculated from moderately T2-weighted turbo SE sequence
Discrimination of benign from malignant hepatic lesions based on their T2-relaxation times calculated from moderately T2-weighted turbo SE sequence
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DOI：
10.1007/s00330-002-1366-6
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发表时间：
2002-09-01
影响因子：
5.9
通讯作者：
Pruszynski, B
中科院分区：
文献类型：
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作者：
Cieszanowski, A;Szeszkowski, W;Pruszynski, B
使用MRI鉴别血管瘤与其他肝肿瘤通常依赖于重T2加权图像的评价。本研究旨在评估中等T2加权快速自旋回波（TSE）序列计算的T2弛豫时间在表征肝脏局灶性病变（包括肝脏恶性肿瘤、局灶性结节增生（FNH）、血管瘤和囊肿）中的价值。52例患者共114个病灶（恶性肿块61个，局灶性结节增生6个，血管瘤28个，囊性病变19个），均采用1.5-T系统双回波TSE序列进行检查（TR=1800 ms; TEeff 1=40 ms; TEeff 2 =40 ms）。2=120 ms）。测量肝脏信号强度（SI）以及所有病灶的SI，然后计算T2弛豫时间。肝脏的平均T2时间为54 ms（8 ms），FNH为66 ms（7 ms），恶性肝脏病变为85 ms（17 ms），血管瘤为155 ms（35 ms），囊性病变为583 ms（369 ms）。大多数恶性肝脏病变在67和116 ms的阈值之间最好区分，产生90%的灵敏度和94%的特异性。恶性肿瘤假阴性6例，假阳性3例（血管瘤2例，FNH 1例）。计算T2弛豫时间从双回波TSE序列与中等T2加权允许恶性和良性肝脏病变之间的区分具有较高的敏感性和特异性。
The differentiation of hemangioma from other hepatic neoplasms using MRI usually relies on the evaluation of heavily T2-weighted images. The aim of this study was to assess the value of T2-relaxation times calculated from moderately T2-weighted turbo spin-echo (TSE) sequence in characterization of focal hepatic lesions, including hepatic malignancies, focal nodular hyperplasia (FNH), hemangioma, and cyst. Fifty-two patients with 114 proven lesions (61 malignant masses, 6 focal nodular hyperplasias, 28 hemangiomas, 19 cystic lesions) were examined on 1.5-T system using a double-echo TSE sequence (TR=1800 ms; TEeff 1=40 ms; TEeff. 2=120 ms). Signal intensities (SI) of the liver as well as SI of all lesions were measured, and then the T2-relaxation times were calculated. The mean T2 time for the liver was 54 ms ( 8 ms), for FNH 66 ms ( 7 ms), for malignant hepatic lesions 85 ms ( 17 ms), for hemangiomas 155 ms ( 35 ms), and for cystic lesions 583 ms ( 369) ms. Most malignant hepatic lesions were best differentiated between the thresholds of 67 and 116 ms, generating a sensitivity of 90% and a specificity of 94%. There were six false-negative diagnoses of malignant tumor and three false-positive cases (two hemangiomas and one FNH). Calculation of the T2-relaxation times obtained from the double-echo TSE sequence with moderate T2-weighting allowed differentiation between malignant and benign hepatic lesions with high sensitivity and specificity.