Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases.
Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases.
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DOI：
10.1016/j.livres.2018.01.001
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发表时间：
2018-03-01
期刊：
影响因子：
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通讯作者：
Feldstein, Ariel E
中科院分区：
文献类型：
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作者：
Eguchi, Akiko;Feldstein, Ariel E
脂肪性肝病、非酒精性脂肪性肝病(NAFLD)和酒精性肝病(ALD)是全球慢性肝病最常见的原因。NAFLD和ALD可发展为更严重的疾病形式，包括非酒精性脂肪性肝炎(NASH)和酒精性脂肪性肝炎(ASH)。在这两种情况下，中心致病事件包括肝细胞死亡、肝脏炎症、病理性血管生成和纤维化，其次是肝硬变和癌症。在过去的几年里，细胞外小泡(EVS)被认为是有效的细胞间通讯工具，它含有来自起始细胞的细胞和应激特异的货物，并能够将这些货物转移到靶细胞或受体细胞。在这篇综述中，我们着重于越来越多的证据支持EVS在NASH和ASH的病理生理学中发挥作用，以及它们作为这些疾病的新生物标记物的潜在作用。
Fatty liver diseases, non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common causes of chronic liver disease around the world. NAFLD and ALD can progress towards a more severe form of the disease, including as non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH). In both instances central pathogenic events include hepatocyte death, liver inflammation, pathological angiogenesis, and fibrosis, followed by cirrhosis and cancer. Over the last few years, extracellular vesicles (EVs) have been identified as effective cell-to-cell communicators that contain a cell- and stress-specific cargo from the cell of origin and are capable of transferring this cargo to a target or acceptor cell. In this review, we focus on the growing evidence supporting a role for EVs in the pathophysiology of NASH and ASH as well as their potential roles as targets for novel biomarkers for these conditions.