Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening
Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening
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DOI：
10.1111/liv.13682
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发表时间：
2018-02-01
影响因子：
6.7
通讯作者：
Kutala, Blaise K.
中科院分区：
文献类型：
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作者：
Marcellin, Patrick;Kutala, Blaise K.
CLD代表了一个重要的，但肯定被低估的全球公共卫生问题。CLD是高度流行和沉默的，与不同的，有时相关的原因。这些疾病的病因分布正在慢慢改变，在未来十年内，病毒引起的CLD的比例肯定会显著下降，而NASH的比例会增加。迫切需要采取有效的全球行动，包括教育、预防和早期诊断，以管理和治疗慢性肝病，从而预防与糖尿病相关的发病率和死亡率。我们的作用是提高公众、医疗保健专业人员和公共卫生当局的认识，鼓励采取积极的早期管理政策，减少这些疾病的短期和长期公共卫生负担。由于坏死性炎症是CLD进展的关键机制，因此应及早发现。因此，需要对CLD进行大规模筛查。ALT水平是肝脏坏死性炎症的一个简单而廉价的标志物，可能是这个过程中的一线工具。
CLDs represent an important, and certainly underestimated, global public health problem. CLDs are highly prevalent and silent, related to different, sometimes associated causes. The distribution of the causes of these diseases is slowly changing, and within the next decade, the proportion of virus-induced CLDs will certainly decrease significantly while the proportion of NASH will increase. There is an urgent need for effective global actions including education, prevention and early diagnosis to manage and treat CLDs, thus preventing cirrhosis-related morbidity and mortality. Our role is to increase the awareness of the public, healthcare professionals and public health authorities to encourage active policies for early management that will decrease the short- and long-term public health burden of these diseases. Because necroinflammation is the key mechanism in the progression of CLDs, it should be detected early. Thus, large-scale screening for CLDs is needed. ALT levels are an easy and inexpensive marker of liver necroinflammation and could be the first-line tool in this process.