Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections.
Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections.
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趋化因子的作用和免疫细胞在寄生虫感染中的运输。
DOI：
10.2174/1573395509666131217000000
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发表时间：
2013
影响因子：
--
通讯作者：
Wilson EH
中科院分区：
文献类型：
--
作者：
McGovern KE;Wilson EH
寄生虫是多种真核病原体，具有复杂的生命周期。它们的清除或在哺乳动物宿主内的控制需要免疫系统的协调努力。被招募到感染区域的细胞类型可以对抗疾病，促进寄生虫的复制和存活，或者有助于疾病病理。细胞招募的地点和时机可能是至关重要的。在这篇综述中，我们探讨了趋化因子在协调和平衡免疫反应中所起的作用，以实现在不促进病理的情况下对寄生虫复制的最佳控制。
Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the immune response to achieve optimal control of parasite replication without promoting pathology.