Serum Concentrations of Markers of TNFα and Fas-Mediated Pathways and Renal Function in Nonproteinuric Patients with Type 1 Diabetes

Serum Concentrations of Markers of TNFα and Fas-Mediated Pathways and Renal Function in Nonproteinuric Patients with Type 1 Diabetes
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DOI:
10.2215/cjn.03010608
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发表时间:
2009-01-01
影响因子:
9.8
通讯作者:
Krolewski, Andrzej S.
Krolewski, Andrzej S.
中科院分区:
医学1区
文献类型:
--
作者:
Niewczas, Monika A.;Ficociello, Linda H.;Krolewski, Andrzej S.

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背景和目的:我们研究的目的是检查 TNF 和 Fas 通路的血清标记物与 1 型糖尿病 (T1DM) 且无蛋白尿受试者中基于半胱氨酸蛋白酶抑制剂 C 的估计肾小球滤过率 (cC-GFR) 的关系。 设计、设置、参与者和测量:研究组(第二次 Joslin 肾脏研究)包括 T1DM 和正常白蛋白尿 (NA) 的患者 (n = 363) 或微量白蛋白尿 (MA) 01 = 304)。肾功能受损(cC-GFR
Background and objectives: The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria.Design, setting, participants, & measurements: The study group (the 2nd Joslin Kidney Study) comprised patients with T1DM and normoalbuminuria (NA) (n = 363) or microalbuminuria (MA) 01 = 304). Impaired renal function (cC-GFR