Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex.
Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex.
复制标题
I 类代谢型谷氨酸激动剂 DHPG 对视觉皮层的影响。
DOI：
10.1152/jn.2001.86.4.1622
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发表时间：
2001
影响因子：
2.5
通讯作者：
Daw,NW
中科院分区：
文献类型：
--
作者：
Jin,XT;Beaver,CJ;Ji,Q;Daw,NW
代谢型谷氨酸受体在视皮层中具有多种作用，这取决于动物的年龄、皮层的层和受体的组。在这里，我们描述了这些影响组I受体，使用在体内和体外制剂。代谢型I族谷氨酸受体激动剂3，5-二羟基苯甘氨酸（DHPG）增强大鼠视皮层脑片对N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）的反应。它也增加了，最初，在猫的视觉皮层的视觉反应。这两种效应在3-4周龄时最大，到10周龄时下降至不显著。两者在皮层的下层也是最大的，这解释了为什么一般代谢型谷氨酸激动剂1 S，3R氨基环戊烷-1，3-二羧酸（ACPD）的促进作用仅在下层观察到。在猫的视觉皮层中，在最初的兴奋效应之后，长时间应用DHPG会产生抑郁。我们还发现，DHPG促进NMDA反应的快速尖峰细胞，这是抑制性的，提供了部分解释。因此，I组代谢型谷氨酸受体具有多种作用，其在视皮层中随层和年龄而变化。
Metabotropic glutamate receptors have a variety of effects in visual cortex that depend on the age of the animal, the layer of the cortex, and the group of the receptor. Here we describe these effects for group I receptors, using both in vivo and in vitro preparations. The metabotropic group I glutamate receptor agonist 3,5 dihydroxyphenylglycine (DHPG) potentiates the responses toN-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in slices of rat visual cortex. It also increases, initially, the visual response in the cat visual cortex. Both these effects are largest at 3–4 wk of age and decline to insignificance by 10 wk of age. Both are also largest in lower layers of cortex, which explains why the facilitatory effects found with the general metabotropic glutamate agonist 1S,3R aminocyclopentane-1,3-dicarboxylic acid (ACPD) are observed only in lower layers. Prolonged application of DHPG in the cat visual cortex, after the initial excitatory effect, produces depression. We also found that DHPG facilitates the NMDA response in fast-spiking cells, which are inhibitory, providing a partial explanation for this. Thus there are multiple effects of group I metabotropic glutamate receptors, which vary with layer and age in visual cortex.