Heinz R. Schelbert, MD, PhD. (Born 1939)
Heinz R. Schelbert, MD, PhD. (Born 1939)
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海因茨·R·谢尔伯特（Heinz R. Schelbert），医学博士、哲学博士。
DOI：
10.1007/s12350-019-02001-6
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发表时间：
2020
影响因子：
2.4
通讯作者：
the History Corner
中科院分区：
文献类型：
--
作者：
F. Wackers;the History Corner
。30多年前，《新英格兰医学杂志》发表了一篇里程碑式的文章，描述了一种用于识别存活的缺血心肌患者的成像方法。这份手稿是海因茨·R·舍尔伯特博士和他的合著者的创意。在这项开创性的工作中描述的概念需要比较局部心肌血流灌注，用N13-氨测量和心肌葡萄糖代谢，用F18-脱氧葡萄糖(FDG)测量。维持葡萄糖利用的低灌注区被认为是存活的缺血心肌的标志，这预示着血管重建术后心功能的改善。这一重要的错配模式及其临床意义已被众多研究人员证实。谢尔伯特博士于1939年11月5日出生于德国维尔茨堡。他的父亲是一名物理学家，母亲是一名教师。作为一名高中生，亨氏有很多爱好，比如历史、古典音乐、绘画和摄影，但没有医学。在高中时，他曾短暂地担任过摄影记者。然而，也许是为了通向更稳定的未来，他选择了维尔茨堡大学医学院。这样做，他遵循了一个家庭传统，因为他的许多家庭成员都是医生。亨氏非常喜欢医学院，觉得它既刺激又令人兴奋。他于1964年从医学院毕业，一年后获得博士学位，并发表了一篇关于药物对颅内压影响的博士论文。为了在美国接受进一步的医学培训，亨氏加入了文特纳基金会的美国交流计划，让年轻的德国医生到美国接受培训。1965年，海因茨在德国克莱夫的圣安东尼乌斯医院进行了常规的轮换实习，之后于1966年在美国费城的仁慈天主教医疗中心(MCMC)接受了轮换实习。事实证明，这是一次关键的人生经历。舍尔伯特博士还记得，在一个陌生且要求苛刻的临床环境中长时间工作所带来的挑战。最终，他欣赏并享受了这份工作。1967年，他在MCMC完成了内科住院医师培训，继续他的临床训练。他对临床心脏病学的接触促使亨氏申请了心血管疾病研究生培训。他被接纳为心脏病专家尤金·布朗沃尔德博士和小约翰·罗斯博士以及核内科医生威廉·L·阿什本的研究员。这些医生已经从NIH搬到了加州大学圣地亚哥分校的新医学院。1968年至1969年，亨氏在圣地亚哥从事心血管基础研究。1970年，他回到费城完成临床内科实习，1971年，他回到德国，在杜塞尔多夫大学获得心脏病学奖学金。在德国期间，他继续他的研究活动，并在同行评议的德语医学期刊上发表了一些文章。1972年，阿什伯恩博士给海因茨提供了一个职位，在加州大学圣地亚哥分校担任心脏病助理研究专家。海因茨通过了美国核医学委员会的考试，并于1976年被提升为放射学助理教授。转载请求：Frans J.Th。韦克斯，医学博士，耶鲁医学院博士，美国康涅狄格州纽黑文；frans.wacker@yale.edu J Nucl Medicol 2020；27：25-7.1071-3581/$34.00版权所有2020美国核心脏病学会。
. Over 3 decades ago, the New England Journal of Medicine published a landmark article describing an imaging approach to identify patients with viable ischemic myocardium. The manuscript was the brainchild of Dr. Heinz R. Schelbert and his co-authors. The concept described in this groundbreaking work required a comparison of regional myocardial perfusion, measured with N13-ammonia and myocardial glucose metabolism, measured with F18-fluorodeoxyglucose (FDG). Regions of decreased perfusion with maintained glucose utilization was identified as a hallmark of viable ischemic myocardium, which was predictive of improvement of ventricular function after revascularization. This important mismatch pattern and its clinical significance have been confirmed by numerous investigators. Dr. Schelbert was born in Würzburg, Germany on November 5, 1939. His father was a physicist and his mother a teacher. As a high school student, Heinz had many interests, i.e., history, classical music, painting, and photography, but not medicine. While in high school, he worked briefly as a photojournalist. However, perhaps as a pathway to a more stable future, he chose to go to the University of Würzburg School of Medicine. Doing so, he followed a family tradition as many of his family members were physicians. Heinz enjoyed Medical School very much and found it stimulating and exciting. He graduated from Medical School in 1964 and obtained his PhD degree 1 year later with a doctoral thesis on the effect of medication on intracranial pressure. To receive further medical training in the USA, Heinz joined an American exchange program of the Ventnor Foundation for young German physicians to train in America. After a conventional rotating internship (1965) in the St. Antonius Hospital, Kleve, Germany, Heinz was accepted in 1966 for a rotating internship in the Mercy Catholic Medical Center (MCMC) in Philadelphia, USA. This turned out to be a pivotal life experience. Dr. Schelbert remembers the challenge of long hours of work in an unfamiliar and demanding clinical environment. Ultimately, he appreciated and enjoyed it. He continued his clinical training with a full internal medicine residency (1967) at the MCMC. His exposure to clinical cardiology motivated Heinz to apply for post graduate training in cardiovascular disease. He was accepted as a research fellow to work with cardiologists Drs. Eugene Braunwald and John Ross Jr and nuclear physician William L. Ashburn. These physicians had moved from the NIH to the new medical school at the University of California at San Diego. From 1968 to 1969, Heinz was involved in basic cardiovascular research in San Diego. In 1970, he returned to Philadelphia to complete his clinical internal medicine residency, and in 1971 he went back to Germany for a cardiology fellowship at the University of Düsseldorf. While in Germany, he continued his research activities and published a number of articles in peer-reviewed German-language medical journals. In 1972, Dr. Ashburn offered Heinz a position as an Assistant Research Cardiologist at UC San Diego. Heinz passed the US Nuclear Medicine Board exam and was promoted to Assistant Professor of Radiology in 1976. Reprint requests: Frans J. Th. Wackers, MD, PhD, Yale School of Medicine, New Haven, CT, USA; frans.wackers@yale.edu J Nucl Cardiol 2020;27:25–7. 1071-3581/$34.00 Copyright 2020 American Society of Nuclear Cardiology.