Study of Fgf15 gene expression in developing mouse brain
Study of Fgf15 gene expression in developing mouse brain
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DOI：
10.1016/s1567-133x(03)00059-0
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发表时间：
2003-08-01
影响因子：
1.2
通讯作者：
Martínez, S
中科院分区：
文献类型：
--
作者：
Gimeno, L;Brûlet, P;Martínez, S
成纤维细胞生长因子15（Fgf15）是在发育中的小鼠脑中受Otx 2表达调节的基因（Proc Natl Acad Sci USA 97（2000）14388）。Otx 2基因编码转录因子，并且是脊椎动物胚胎的前神经板和头区域的区域化和发育的基础（Development 124（1997）3639）。此外，最近报道了在Shh信号传导基因的控制下Fgf 15的丘脑表达，Shh信号传导基因在间脑基板中表达（Development 129（2002）4807）。在本工作中，我们分析了Fgf 15在小鼠神经发育过程中的表达模式。Fgf15出现在早期发育的神经上皮中，在Fgf8基因也表达的区域中，并且在后期阶段，在特定的神经细胞组中。Fgf8是一种重要的信号蛋白，在几个胚胎区域具有形态发生活性。Fgf15的表达与Fgf8一样，定位于次级神经管组织者：峡部组织者（IsO）和前神经脊（ANR）。(C)2003 Elsevier Science B.V.保留所有权利。
Fibroblast growth factor 15 (Fgf15) is a gene regulated by the expression of Otx2 in developing mouse brain (Proc Natl Acad Sci USA 97 (2000) 14388). Otx2 gene codes for a transcription factor and is fundamental for the regionalisation and development of the anterior neural plate and cephalic region of the vertebrate embryo (Development 124 (1997) 3639). In addition, the thalamic expression of Fgf15 has been recently reported under the control of Shh signalling gene, expressed in the diencephalic basal plate (Development 129 (2002) 4807). In the present work, we have analysed Fgf15 expression pattern during mouse neural development. Fgf15 appeared early in the developing neural epithelium, in domains where Fgf8 gene is also expressed and, at later stages, in specific groups of neural cells. Fgf8 is an important signalling protein with demonstrated morphogenetic activity in several embryonic regions. Fgf15 expression is localized, like Fgf8, in secondary neural tube organizers: the isthmic organizer (IsO) and the anterior neural ridge (ANR). (C) 2003 Elsevier Science B.V. All rights reserved.