ICER-IIγ is a tumor suppressor that mediates the antiproliferative activity of cAMP
ICER-IIγ is a tumor suppressor that mediates the antiproliferative activity of cAMP
复制标题
ICER-IIγ 是一种肿瘤抑制因子，介导 cAMP 的抗增殖活性
作者：
R. Razavi;J. C. Ramos;G. Yehia;F. Schlotter;C. Molina
第二信使cAMP抑制大多数细胞类型的增殖。cAMP的核反应是由cAMP- responsive Element Modulator （CREM）基因等转录因子介导的。CREM基因的产物之一，转录抑制因子诱导性cAMP早期抑制因子- iγ (icer - iγ)是由cAMP诱导的。icer - iγ在细胞周期的G2/M边界阻断细胞。本研究表明，icer - iγ显著抑制小鼠垂体肿瘤细胞和人绒毛膜癌细胞的生长和DNA合成。细胞生长的这种改变与这些细胞以不依赖于锚定的方式生长和在小鼠中形成肿瘤的能力降低相结合。这些数据表明，icer - iγ是一种肿瘤抑制基因产物，介导cAMP的抗增殖活性。
The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIγ (ICER-IIγ), is induced by cAMP. ICER-IIγ blocks cells at the G2/M boundary of the cell cycle. Here we show that ICER-IIγ dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells. This alteration in cell growth is coupled with reduced ability of these cells to grow in an anchorage-independent manner and to form tumors in mice. These data demonstrate that ICER-IIγ is a tumor suppressor gene product mediating the antiproliferative activity of cAMP.