Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities.
Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities.
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热休克蛋白（Heat shock proteins，HSP）是一种内源性的保护性蛋白，是细胞应激反应的生物标志物，如HSP 70、HSP 60、HSP 90和小分子HSP（small HSP，HSPB）等。热休克蛋白保护细胞和器官，特别是心血管系统，免受有害和细胞毒性条件。最近的注意力集中在热休克蛋白在心房颤动（AF）的不可逆重构中的作用，心房颤动是临床实践中最常见的心律失常，也是死亡率的重要因素。在这篇综述中，我们调查了热休克蛋白与房颤心房重构机制之间的关系。PubMed使用术语“热休克蛋白”和“房颤”及其相关缩写检索了截至2022年7月10日的研究。结果表明，热休克蛋白通过促进心房肌细胞电重构和结构重构，对房颤时心房肌细胞具有细胞保护作用。热休克反应（HSR）衰竭，其次是低水平的热休克蛋白，导致心肌细胞的蛋白质稳态脱轨，这是AF的基础。此外，热休克蛋白在AF的管理中的潜在意义进行了详细讨论。热休克蛋白代表可靠的生物标志物预测和分期AF。热休克蛋白诱导剂可作为新的治疗方式，在术后AF。热休克蛋白诱导，无论是香叶基香叶基丙酮（GGA）或目前正在开发的其他化合物，因此可能是一个有趣的新方法，为AF的上游治疗，一种策略，旨在预防AF，同时最大限度地减少心室promammic风险的传统抗心律失常药物。
Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB). HSPs protect cells and organs, especially the cardiovascular system, against harmful and cytotoxic conditions. More recent attention has focused on the roles of HSPs in the irreversible remodeling of atrial fibrillation (AF), which is the most common arrhythmia in clinical practice and a significant contributor to mortality. In this review, we investigated the relationship between HSPs and atrial remodeling mechanisms in AF. PubMed was searched for studies using the terms “Heat Shock Proteins” and “Atrial Fibrillation” and their relevant abbreviations up to 10 July 2022. The results showed that HSPs have cytoprotective roles in atrial cardiomyocytes during AF by promoting reverse electrical and structural remodeling. Heat shock response (HSR) exhaustion, followed by low levels of HSPs, causes proteostasis derailment in cardiomyocytes, which is the basis of AF. Furthermore, potential implications of HSPs in the management of AF are discussed in detail. HSPs represent reliable biomarkers for predicting and staging AF. HSP inducers may serve as novel therapeutic modalities in postoperative AF. HSP induction, either by geranylgeranylacetone (GGA) or by other compounds presently in development, may therefore be an interesting new approach for upstream therapy for AF, a strategy that aims to prevent AF whilst minimizing the ventricular proarrhythmic risks of traditional anti-arrhythmic agents.
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影响因子：
5.5
作者：
Hamiel, Christine R.;Pinto, Shanti;Wischmeyer, Paul E.
通讯作者：
Wischmeyer, Paul E.
影响因子：
5
作者：
Brundel, Bianca J. J. M.;Henning, Robert H.;Kampinga, Harm H.
通讯作者：
Kampinga, Harm H.
影响因子：
4.3
作者：
Chen, Zhiyu;Shen, Xiaolu;Lai, Jiang
通讯作者：
Lai, Jiang
影响因子：
4.8
作者：
Asea, A;Rehli, M;Calderwood, SK
通讯作者：
Calderwood, SK
DOI：
10.1083/jcb.126.2.305
发表时间：
1994-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Höhfeld J;Hartl FU
通讯作者：
Hartl FU