Role of permeability in the activities of β-lactams against gram-negative bacteria which produce a group 3 β-lactamase
Role of permeability in the activities of β-lactams against gram-negative bacteria which produce a group 3 β-lactamase
复制标题
DOI：
10.1128/aac.43.8.2084
复制
发表时间：
1999-08-01
影响因子：
4.9
通讯作者：
Mitsuhashi, S
中科院分区：
文献类型：
--
作者：
Matsumura, N;Minami, S;Mitsuhashi, S
第3组β-内酰胺酶的产生允许大肠埃希氏菌Call大大提高头孢他啶、头孢匹罗和美罗培南的MIC，但亚胺培南和哌拉西林的MIC仅略有提高。头孢他啶、头孢匹罗和哌拉西林的最大水解速率与Km的比值低于美罗培南和亚胺培南。哌拉西林和美罗培南的渗透系数高于头孢他啶和头孢匹罗。亚胺培南的渗透系数最高。
The production of a group 3 beta-lactamase permitted Escherichia call to raise the MICs of ceftazidime, cefpirome, and meropenem greatly but those of imipenem and piperacillin only slightly. The ratios of maximum rate of hydrolysis to K-m of ceftazidime, cefpirome, and piperacillin were lower than those of meropenem and imipenem for the group 3 beta-lactamase. The permeability coefficients for piperacillin and meropenem were higher than those for ceftazidime and cefpirome. Imipenem had the highest permeability coefficient.