EFFECTS OF FRICTIONAL STIMULATION ON MOUSE EAR EPIDERMIS .2. HISTOLOGIC APPEARANCE AND CELL COUNTS
EFFECTS OF FRICTIONAL STIMULATION ON MOUSE EAR EPIDERMIS .2. HISTOLOGIC APPEARANCE AND CELL COUNTS
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DOI：
10.1111/1523-1747.ep12679356
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发表时间：
1974-01-01
影响因子：
6.5
通讯作者：
MACKENZIE, IC
中科院分区：
文献类型：
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作者：
MACKENZIE, IC
研究了小鼠表皮组织学外观的变化，其结果是每天施加受控摩擦刺激长达35天。摩擦导致角质层增厚，颗粒层和棘层中细胞的大小和数量增加。表皮增厚的程度增加，增加摩擦刺激，增厚后，表皮似乎是耐机械damage.A近似稳定状态的表皮细胞形成和细胞损失的速度重新建立在每日刺激期间和2或3倍的增加，估计细胞从基底层角质层的通过率。结果表明，细胞形成和成熟的速率增加在表皮对机械刺激的适应性反应中起重要作用。
The changes produced in the histologic appearance of mouse epidermis as the result of daily application of a controlled frictional stimulus for periods of up to 35 days were studied. Friction resulted in thickening of the stratum corneum and an increase in the size and number of cells in the stratum granulosum and stratum spinosum. The degree of epidermal thickening was increased by increasing the frictional stimulus, and, after thickening, the epidermis appeared to be resistant to mechanical damage.An approximate steady state in the rate of epidermal cell formation and cell loss was reestablished during the period of daily stimulation and a 2- or 3-fold increase in the rate of passage of cells from the stratum basale to the stratum corneum was estimated. It was concluded that increased rates of cell formation and maturation play an important role in the adaptive response of the epidermis to mechanical stimulation.