Calreticulin: conserved protein and diverse functions in plants
Calreticulin: conserved protein and diverse functions in plants
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DOI：
10.1111/j.1399-3054.2009.01223.x
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发表时间：
2009-06-01
影响因子：
6.4
通讯作者：
Li, Run-Zhi
中科院分区：
文献类型：
--
作者：
Jia, Xiao-Yun;He, Li-Heng;Li, Run-Zhi
钙网蛋白（Calreticulin， CRT）是一种主要存在于内质网（endoplasmic reticulum， ER）中的关键Ca2+结合蛋白，在所有真核生物中高度保守且广泛表达。该蛋白在多种细胞过程中发挥重要作用，包括Ca2+信号传导和蛋白质折叠。尽管钙网蛋白已经在哺乳动物系统中得到了很好的表征，但越来越多的研究表明，植物crt具有许多不同于动物同类的特定性质。近年来植物crt的研究进展突出了crt在植物生长发育以及生物和非生物胁迫响应中的重要意义。在高等植物中至少有两组钙网蛋白同种异构体。CRT的糖基化仅在植物中观察到。在本文中，我们将介绍目前对植物钙网蛋白基因家族、蛋白结构、细胞定位和多种功能的了解。我们还讨论了利用这些信息进行作物遗传改良的前景。
Calreticulin (CRT) is a key Ca2+-binding protein mainly resident in the endoplasmic reticulum (ER), which is highly conserved and extensively expressed in all eukaryotic organisms investigated. The protein plays important roles in a variety of cellular processes including Ca2+ signaling and protein folding. Although calreticulin has been well characterized in mammalian systems, increased investigations have demonstrated that plant CRTs have a number of specific properties different from their animal counterparts. Recent developments on plant CRTs have highlighted the significance of CRTs in plants growth and development as well as biotic and abiotic stress responses. There are at least two distinct groups of calreticulin isoforms in higher plants. Glycosylation of CRT was uniquely observed in plants. In this article, we will describe our current understanding of plant calreticulin gene family, protein structure, cellular localization, and diverse functions in plants. We also discuss the prospects of using this information for genetic improvements of crop plants.