Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: Results from the national epidemiologic survey on alcohol and related conditions
Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: Results from the national epidemiologic survey on alcohol and related conditions
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DOI：
10.4088/jcp.v67n0211
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发表时间：
2006-02-01
影响因子：
5.3
通讯作者：
Grant, BF
中科院分区：
文献类型：
--
作者：
Conway, KP;Compton, W;Grant, BF
目的：介绍具有全国代表性的8种特定药物使用障碍的终生患病率和共病数据，分别为滥用和依赖以及情绪和焦虑障碍。方法：数据来自美国18岁及以上非住院平民人口的代表性样本(N=43,093)。情绪、焦虑和药物使用障碍的诊断基于面对面的个人访谈，使用酒精使用障碍和相关残疾面谈量表-DSM-IV(AUDADIS-IV)。结果：特定的情绪和焦虑障碍与特定的药物使用障碍之间的关联几乎都是积极的，并且具有统计学意义(p<；0.05)。总体而言，依赖比滥用更容易引起联想。情绪障碍比焦虑症更严重，在某些情况下，女性比男性更严重(p<；0.05)。结论：在美国人群中，特定的情绪和焦虑障碍与特定的药物使用障碍之间的共病是普遍存在的。研究结果表明，合并精神障碍可能会增加更多人卷入更严重的非法药物使用障碍的风险，女性情绪和焦虑与药物使用障碍之间的更大共病可能反映了吸毒女性比男性更大的越轨和精神病理。研究结果还表明，药物滥用的预防和干预工作应该针对其他精神疾病。再远一点。药物使用障碍表型的定义应该仔细考虑其他精神疾病，作为病例异质性的有意义的特征。
Objective: To present nationally representative data on the lifetime prevalence and comorbidity of 8 specific drug use disorders, separately for abuse and dependence, and mood and anxiety disorders.Method: Data come from a representative sample (N = 43,093) of the United States civilian, noninstitutional population 18 years and older. Diagnoses of mood, anxiety, and drug Use disorders were based upon face-to-face personal interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV).Results: Associations between specific mood and anxiety disorders and specific drug use disorders were virtually all positive and statistically significant (p < .05). In general, associations were greater for dependence than abuse. greater for mood than anxiety disorders, and in some instances stronger among women than men (p < .05). Large odds ratios also were observed tor individuals with comorbid mood and anxiety disorders.Conclusion: The comorbidity between specific mood and anxiety disorders and specific drug use disorders is pervasive in the U.S. population. Findings suggest that comorbid psychiatric disorders may increase the risk of greater involvement in more serious illicit drug use disorders and that the greater comorbidity between mood and anxiety and drug use disorders among women may reflect greater deviance and psychopathology among drug-using women than men. Findings also suggest that drug abuse prevention and intervention efforts should address other psychiatric conditions. Further. definitions of drug use disorder phenotypes should give careful consideration to other psychiatric conditions as meaningful characteristics of case heterogeneity.