Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy
Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy
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DOI：
10.1016/j.jocn.2019.08.001
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发表时间：
2019-11-01
影响因子：
2
通讯作者：
Pandey, Aditya S.
中科院分区：
文献类型：
--
作者：
Griauzde, Julius;Ravindra, Vijay M.;Pandey, Aditya S.
机械取栓是目前治疗大血管急性缺血性中风（AIS）的前沿技术。选择性动脉内（IA）通路为AIS的神经保护开辟了一条新的途径，有可能最大化局部效益，同时最小化全身效应。在细胞水平上，神经保护策略旨在减少炎症和自由基的形成，维持血脑屏障的保真度，防止细胞死亡。正在研究的策略包括注射神经保护剂、注射干细胞和选择性低温注射。在这篇技术报告中，我们简要讨论了AIS的病理机制，并强调了通过IA途径选择性给药的潜在神经保护策略。(C) 2019 Elsevier Ltd.版权所有。
Mechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential to maximize local benefit while minimizing systemic effects. On a cellular level, neuroprotective strategies are aimed at reducing inflammation and free-radical formation, maintaining blood-brain barrier fidelity, and preventing cellular death. Strategies under investigation include IA infusion of neuroprotective agents, IA administration of stem cells, and selective IA hypothermia. In this technical report, we briefly discuss pathologic mechanisms in AIS and highlight potential neuroprotective strategies that are administered selectively via the IA route. (C) 2019 Elsevier Ltd. All rights reserved.