Control of secondary flow in concentrically traveling flow on centrifugal microfluidics
Control of secondary flow in concentrically traveling flow on centrifugal microfluidics
复制标题
离心微流控同心行进流中二次流的控制
DOI：
10.1007/s10404-013-1194-9
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发表时间：
2013
影响因子：
2.8
通讯作者：
Yuzuru Takamura
中科院分区：
文献类型：
--
作者：
Yoshiaki Ukita;Yuzuru Takamura
本文对离心式微流控装置上的条状层流流态进行了基础性研究，旨在实现一种基于沉降的连续模式颗粒分离技术。设计了具有同心集成微通道的微流体通道，并研究了通道内的流动形态。作为初步结果，观察到了显著的二次流。我们的结论是，这种二次流的起源不是Dean力，因为在直线微通道中观察到了这种二次流，而在弯曲通道中没有观察到它。通过模拟和实验研究了流型的转变，确定了流型与转速的依赖关系，表明二次流的起源是科里奥利力。二次流的重要性通过调节圆盘的转速来控制，而流量和层流的流型由条状流型来控制。
This paper reports a fundamental study of the stripe laminar flow pattern on a centrifugal microfluidic device with the goal of realizing a sedimentation-based, continuous mode particle separation technique. Microfluidic channels were designed with a concentrically integrated microchannel, and the patterning of the flow in the channel was investigated. A significant secondary flow was observed as a preliminary result. We conclude that the origin of this secondary flow was not the Dean force, because it was observed in a straight microchannel, but was not observed in curved channel during the spinning of the system at rest. The transition of the pattern was investigated using a simulation and experiment, and the flow pattern’s dependence on the rotational speed was determined, which suggested that the origin of the secondary flow was the Coriolis force. The significance of the secondary flow was controlled by adjusting the rotational speed of the disk, and the flow rate and laminar flow patterns were controlled by the stripe flow pattern.