Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors.
Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors.
复制标题
逆转胆固醇转运的初始步骤：短命胆固醇受体的作用。
DOI：
10.1093/eurheartj/11.suppl_e.218
复制
发表时间：
1990
影响因子：
39.3
通讯作者：
Fielding,CJ
中科院分区：
文献类型：
--
作者：
Francone,OL;Fielding,CJ
The early metabolism of cell-derived cholesterol was followed during the interaction of normolipaemic native plasma with cultured cell monolayers labelled to high specific activity with3H-cholesterol. Kinetic analysis indicated that initial processing involved several prebeta-migrating high-density lipoprotein (HDL) species. A small prebeta species, the initial acceptor, was first converted to a lipoprotein whose composition predicts a discoidal structure. The free cholesterol content of this war then esterified by lecithin: cholesterol acyltransferase, and its cholesterol converted to the alpha mobility of spheroidal mature HDL the binding of apolipoprotein A-II. These studies follow the genesis of HDL in plasma from peripheral cell membrane cholesterol.
