Triglyceride level and soft drink consumption predict nonalcoholic fatty liver disease in nonobese male adolescents
Triglyceride level and soft drink consumption predict nonalcoholic fatty liver disease in nonobese male adolescents
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DOI：
10.1111/hepr.13889
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发表时间：
2023-03-03
影响因子：
4.2
通讯作者：
Fujishiro，Mitsuhiro
中科院分区：
文献类型：
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作者：
Kado，Akira;Inoue，Yukiko;Fujishiro，Mitsuhiro
目的分析非肥胖男性青少年非酒精性脂肪性肝病 (NAFLD) 的不同代谢危险因素，检查 NAFLD 与男性青少年代谢综合征临床参数（包括运动和软饮料摄入量）之间的关系。方法总共 134 名接受第一年健康检查的男性大学生（非肥胖，n = 78；肥胖，n = 56）根据腹部超声检查分为 NAFLD 组和非 NAFLD 组（澳大利亚）调查结果。在非肥胖学生中检查了 NAFLD 与代谢参数（包括体重指数 (BMI) 和 AUS 评分）之间的关系。结果与高血压、腹部脂肪、肝损伤、血脂异常和糖耐量受损相关的代谢因素在非肥胖学生中明显少于肥胖学生。上述因素和软饮料消费在 NAFLD 组中比非 NAFLD 组中更为常见。非肥胖学生的单变量和多变量分析显示，NAFLD 组中甘油三酯水平（比值比 [OR]，1.06；95% 置信区间 [CI]，1.01–1.10，p= 0.001）较高，软饮料饮用量（OR，36.8；95% CI，3.69–368，p< 0.001）更常见结论 甘油三酯水平和软饮料摄入量有助于检测非肥胖男性青少年的 NAFLD。我们的研究结果可以提供与非肥胖青少年 NAFLD 和代谢综合征相关的有用信息。
AimDifferential metabolic risk factors of nonalcoholic fatty liver disease (NAFLD) in nonobese male adolescents were analyzed examining relationships between NAFLD and clinical parameters of metabolic syndrome, including exercise and soft drink consumption, in male adolescents.MethodsIn total, 134 male university students (nonobese,n= 78; obese,n= 56) who underwent the first‐year health checkup were divided into the NAFLD and non‐NAFLD groups based on abdominal ultrasonography (AUS) findings. Relationships between NAFLD and metabolic parameters, including body mass index (BMI) and AUS score, were examined in nonobese students.ResultsMetabolic factors associated with hypertension, abdominal fat, liver damage, dyslipidemia, and impaired glucose tolerance were significantly less common in nonobese students than in obese students. The aforementioned factors and soft drink consumption were significantly more common in the NAFLD group than in the non‐NAFLD group. The univariate and multivariate analyses of nonobese students showed that the triglyceride level (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.01–1.10,p= 0.001) was higher and soft drink consumption (OR, 36.8; 95% CI, 3.69–368,p< 0.001) was more common in the NAFLD group than the non‐NAFLD group.ConclusionsTriglyceride level and soft drink consumption could aid in the detection of NAFLD in nonobese male adolescents. Our findings could provide useful information related to NAFLD and metabolic syndrome in nonobese adolescents.