Lower airway inflammation in infants and young children with cystic fibrosis
Lower airway inflammation in infants and young children with cystic fibrosis
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DOI：
10.1164/ajrccm.156.4.96-11058
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发表时间：
1997-10-01
影响因子：
24.7
通讯作者：
Phelan, PD
中科院分区：
文献类型：
--
作者：
Armstrong, DS;Grimwood, K;Phelan, PD
气道炎症是囊性纤维化（CF）肺病的重要组成部分。为了确定这是否在疾病早期开始，在感染发生之前，我们检查了46例新生儿筛查项目确定的6个月以下新诊断CF婴儿的支气管肺泡灌洗液（BAL）。这些婴儿被分为三组：10名没有出现呼吸道症状或接受抗生素治疗，并且他们的BAL液中不存在病原体; 18名有明确的下呼吸道病毒或细菌（大于或等于10（5）CFU/ml）感染证据;其余18名有呼吸道症状，服用抗生素，或
Airway inflammation is an important component of cystic fibrosis (CF) lung disease. To determine whether this begins early in the illness, before the onset of infection, we examined bronchoalveolar lavage (BAL) fluid from 46 newly diagnosed infants with CF under the age of 6 mo identified by a neonatal screening program. These infants were divided in-to three groups: 10 had not experienced respiratory symptoms or received antibiotics and pathogens were absent in their BAL fluid; 18 had clear evidence of lower respiratory viral or bacterial (greater than or equal to 10(5) CFU/ml) infection; and the remaining 18 had either respiratory symptoms, taken antibiotics, or had