Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
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DOI：
10.3390/nu11081757
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发表时间：
2019-08-01
期刊：
影响因子：
5.9
通讯作者：
Bassaganya-Riera, Josep
中科院分区：
文献类型：
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作者：
Atkinson, Fiona S.;Villar, Agusti;Bassaganya-Riera, Josep
脱落酸（阿坝）可以通过激活羊毛硫氨酸合成酶C样2（LANCL 2）来改善哺乳动物的葡萄糖稳态并减轻炎症。本研究探讨了两个无花果果实提取物（FFE），每个管理在两个不同的阿坝剂量，血糖指数（GI）和胰岛素指数（II）的标准葡萄糖饮料的影响。在一项随机、双盲交叉研究中，10名健康成人饮用4种含有FFE的测试饮料，在2小时内定期评估餐后葡萄糖和胰岛素，以确定GI和II反应。含有200 mg FFE-50 x和1200 mg FFE-10 x的测试饮料分别使GI值显著降低了-25%（P = 0.001）和-24%（P = 0.002）。与参考饮料相比，两种较低剂量的FFE也降低了GI值（约-14%），但差异未达到统计学显著性。向葡萄糖溶液中添加FFE显著降低了所有剂量下的II值，并显示出明显的剂量-反应降低：FFE-50 x，100 mg和200 mg 05）和-24%（P = 0.01））以及600 mg和1200 mg的FFE-10 x（分别为-16%（P < 0.05）和-24%（P = 0.01））。FFE补充是一种很有前途的营养干预措施，用于管理急性餐后血糖和胰岛素稳态，并且它是慢性代谢紊乱如糖尿病前期和2型糖尿病的血糖管理的可能的连续治疗。
Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50x and 1200 mg FFE-10x significantly reduced GI values by -25% (P = 0.001) and -24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately -14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50x at 100 mg and 200 mg (-14% (P < 0.05) and -24% (P = 0.01), respectively) and FFE-10x at 600 mg and 1200 mg (-16% (P < 0.05) and -24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus.