Behavioral approach system (BAS) sensitivity and bipolar spectrum disorders: A retrospective and concurrent behavioral high-risk design
Behavioral approach system (BAS) sensitivity and bipolar spectrum disorders: A retrospective and concurrent behavioral high-risk design
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DOI：
10.1007/s11031-006-9003-3
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发表时间：
2006-06-01
影响因子：
4.8
通讯作者：
Nusslock, Robin
中科院分区：
文献类型：
--
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Nusslock, Robin
在这篇文章中，我们测试了双相情感障碍的行为接近系统（BAS）超敏反应模型的脆弱性假设。我们采用回顾性和同时进行的行为高危设计，研究自我报告的BAS敏感性是否能预测双相情感障碍的终生诊断以及与双相情感障碍相关的症状和人格特征。参与者高（HBAS; n = 28）或中度（MBAS; n = 24）BAS敏感性，并给予终身精神病诊断访谈和自我报告的双相症状倾向，当前症状和人格特征的措施与双相。HBAS参与者比MBAS参与者更有可能终生诊断为双相谱系障碍，但与MBAS参与者诊断为单相抑郁症的可能性没有差异。此外，HBAS组表现出更高的冲动性和倾向于轻躁狂症状比MBAS组，和BAS奖励反应预测轻躁狂人格特征。最后，高行为抑制系统（BIS）的敏感性与倾向和当前的抑郁症状。
In this article, we tested the vulnerability hypothesis of the behavioral approach system (BAS) hypersensitivity model of bipolar disorders. We examined whether self-reported BAS sensitivity predicts lifetime bipolar spectrum diagnoses as well as symptoms and personality characteristics associated with bipolar disorder using a retrospective and concurrent behavioral high-risk design. Participants with high (HBAS; n = 28) or moderate (MBAS; n = 24) BAS sensitivity were selected and given a lifetime psychiatric diagnostic interview and self-report measures of proneness to bipolar symptoms, current symptoms, and personality characteristics relevant to bipolarity. HBAS participants were significantly and substantially more likely to have a lifetime bipolar spectrum disorder diagnosis than were MBAS participants, but did not differ from MBAS participants in their likelihood of a unipolar depression diagnosis. Also, the HBAS group exhibited higher impulsivity and proneness to hypomanic symptoms than the MBAS group, and BAS-reward responsiveness predicted hypomanic personality characteristics. Finally, high behavioral inhibition system (BIS) sensitivity was associated with proneness to and current depressive symptoms.