Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics
Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics
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DOI：
10.1016/s0162-3109(00)80299-4
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发表时间：
2000-08-01
期刊：
影响因子：
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通讯作者：
Lambris, JD
中科院分区：
文献类型：
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作者：
Sahu, A;Lambris, JD
除了在免疫防御中发挥重要作用外，补体系统在许多临床情况下有助于组织损伤。因此，迫切需要开发治疗上有效的补体抑制剂来防止这些不良反应。这个概念虽然古老，但直到最近才受到科学界的关注。利用补体缺乏、基因敲除和转基因动物产生的疾病动物模型的数据，以及证明补体蛋白在许多重要组织部位（包括大脑）产生的数据，吸引了生物技术领域和大型制药公司的许多基础研究科学家和应用科学家的兴趣。这种兴趣的复苏产生了补体抑制领域的大量新信息，在这篇文章中，我们全面回顾了补体抑制剂领域的最新信息。(C) 2000 Elsevier Science B.V.版权所有
In addition to its essential role in immune defense, the complement system contributes to tissue damage in many clinical conditions. Thus, there is a pressing need to develop therapeutically effective complement inhibitors to prevent these adverse effects. This concept, though old, received little scientific attention until recently. Data from animal models of diseases that have been produced using complement-deficient, knockout, and transgenic animals, as well as data demonstrating that complement proteins are produced in many important tissue sites (including the brain) have attracted the interest of many basic research scientists and applied scientists from the biotechnology field and larger pharmaceutical firms. This resurgence of interest has generated a wealth of new information in the field of complement inhibition, In this article, we comprehensively review up-to-date information in the field of complement inhibitors. (C) 2000 Elsevier Science B.V. All rights reserved.