Animal models of polymicrobial pneumonia.
Animal models of polymicrobial pneumonia.
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DOI：
10.2147/dddt.s70993
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Bregeon F
中科院分区：
文献类型：
--
作者：
Hraiech S;Papazian L;Rolain JM;Bregeon F
肺炎是严重、有时危及生命的感染的主要原因之一。肺炎的生理病理学已被广泛研究，为这种疾病的新治疗方法的开发提供了信息。除了体外研究，动物模型已广泛应用于肺炎领域。已经描述了几个模型，这些模型提供了对不同环境下的肺炎和各种病原体的更好的理解。然而，一种病原体导致一种感染的概念受到了挑战，最近的流感流行表明，一些病原体显示出高度毒力潜力。虽然“两击”动物模型已被用于研究传染病，但在肺炎中描述这些模型的人很少。因此，本综述的目的是提供这一领域现有文献的概述，描述研究充分的和不常见的病原体联系，并总结从这些信息中获得的主要见解。
Pneumonia is one of the leading causes of severe and occasionally life-threatening infections. The physiopathology of pneumonia has been extensively studied, providing information for the development of new treatments for this condition. In addition to in vitro research, animal models have been largely used in the field of pneumonia. Several models have been described and have provided a better understanding of pneumonia under different settings and with various pathogens. However, the concept of one pathogen leading to one infection has been challenged, and recent flu epidemics suggest that some pathogens exhibit highly virulent potential. Although “two hits” animal models have been used to study infectious diseases, few of these models have been described in pneumonia. Therefore the aims of this review were to provide an overview of the available literature in this field, to describe well-studied and uncommon pathogen associations, and to summarize the major insights obtained from this information.