Memory B cell and antibody responses to flavivirus infection and vaccination.
Memory B cell and antibody responses to flavivirus infection and vaccination.
复制标题
DOI：
10.12703/r/10-5
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Adam A;Cuellar S;Wang T
黄病毒是一组蚊媒或扁虱传播的单链RNA病毒，可在人类和动物中引起广泛的临床症状，包括无症状、流感样发热、出血热、脑炎、出生缺陷和死亡。他们中的许多人没有获得许可的疫苗供人类使用。记忆B细胞的发育和中和抗体反应的诱导，对于控制黄病毒的感染和传播是重要的，已被用作疫苗疗效的生物标志物。在这篇综述中，我们将讨论黄病毒感染和疫苗接种的临床标本和动物模型研究中关于记忆B细胞和抗体反应的最新发现，重点是几种临床上重要的黄病毒，包括登革热、西尼罗河病毒、黄热病和寨卡病毒。
Flaviviruses are a group of mosquito- or tick-borne single-stranded RNA viruses that can cause a wide range of clinical manifestations in humans and animals, including asymptomatic, flu-like febrile illness, hemorrhagic fever, encephalitis, birth defects, and death. Many of them have no licensed vaccines available for human use. Memory B cell development and induction of neutralizing antibody responses, which are important for the control of flavivirus infection and dissemination, have been used as biomarkers for vaccine efficacy. In this review, we will discuss recent findings on memory B cells and antibody responses from studies in clinical specimen and animal models of flavivirus infection and vaccination with a focus on several clinically important flaviviruses, including dengue, West Nile, yellow fever, and Zika viruses.