CORRELATION BETWEEN INVIVO AND INVITRO EFFICACY OF ANTIMICROBIAL AGENTS AGAINST FOREIGN-BODY INFECTIONS
CORRELATION BETWEEN INVIVO AND INVITRO EFFICACY OF ANTIMICROBIAL AGENTS AGAINST FOREIGN-BODY INFECTIONS
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DOI：
10.1093/infdis/162.1.96
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发表时间：
1990-07-01
影响因子：
6.4
通讯作者：
ZIMMERLI, W
中科院分区：
文献类型：
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作者：
WIDMER, AF;FREI, R;ZIMMERLI, W
植入物相关感染通常对抗生素治疗具有耐药性。常规敏感性试验不能预测治疗成功。因此，寻求与器械相关感染中的药物有效性更好相关的体外试验。研究了6种不同抗生素对耐甲氧西林表皮葡萄球菌的活性。用豚鼠组织笼动物模型进行体内研究;用最低抑制和杀菌浓度进行体外研究，对生长期和静止期微生物进行时间杀灭研究，对玻璃粘附S.表皮。药物对静止和粘附微生物的有效性，但不是最低抑制浓度，预测了器械相关感染的结局。利福平治愈了12例感染中的12例，也是任何体外试验中最有效的药物。同样，环丙沙星根除异物感染的失败与其对静止期和粘附性链球菌的低疗效有关。表皮。
Implant-associated infections are often resistant to antibiotic therapy. Routine sensitivity tests fail to predict therapeutic success. Therefore experimental in vitro tests were sought that would better correlate with drug efficacy in device-related infections. The activity of six different antibiotics against methicillin-resistant Staphylococcus epidermidis was investigated. In vivo studies were performed with the guinea pig tissue-cage animal model; in vitro studies with minimum inhibiting and bactericidal concentrations, time-kill studies of growing and stationary-phase microorganisms, the killing of glass-adherent S. epidermidis. Drug efficacy on stationary and adherent microorganisms, but not minimum inhibiting concentrations, predicted the outcome of device-related infections. Rifampin cured 12 of 12 infections and was also the most efficient drug in any experimental in vitro test. Similarly, the failure of ciprofloxacin to eradicate foreign body infections correlated with its low efficacy on stationary-phase and adherent S. epidermidis.