Trends in Exposure to Chemicals in Personal Care and Consumer Products.
Trends in Exposure to Chemicals in Personal Care and Consumer Products.
复制标题
DOI：
10.1007/s40572-015-0065-9
复制
发表时间：
2015-12-01
影响因子：
7.9
通讯作者：
Ye, Xiaoyun
中科院分区：
文献类型：
--
作者：
Calafat, Antonia M;Valentin-Blasini, Liza;Ye, Xiaoyun
合成有机化学品可用于个人护理和消费品。关于这些化学物质对人类健康的潜在影响的数据是有限的，有时甚至是相互矛盾的，但由于其中一些化学物质在实验动物身上是有毒的，替代化合物正在进入消费市场。然而，关于随后接触原始化学品及其替代品的趋势的资料有限。生物监测（测量人体内化学物质或其代谢物的浓度）为暴露评估提供了宝贵的信息。我们使用邻苯二甲酸盐和双酚a -已知的工业化学品和有机磷杀虫剂作为案例研究，以显示这些化学品及其替代品（例如，其他邻苯二甲酸盐，非邻苯二甲酸盐增塑剂，各种双酚类，拟除虫菊酯杀虫剂）在美国普通人群中的暴露趋势。我们将美国的趋势与加拿大和德国的国家趋势进行了比较。在这些普通人群中，接触原始化合物的情况仍然普遍存在，但接触替代化学品的情况可能正在增加。
Synthetic organic chemicals can be used in personal care and consumer products. Data on potential human health effects of these chemicals are limited-sometimes even contradictory-but because several of these chemicals are toxic in experimental animals, alternative compounds are entering consumer markets. Nevertheless, limited information exists on consequent exposure trends to both the original chemicals and their replacements. Biomonitoring (measuring concentrations of chemicals or their metabolites in people) provides invaluable information for exposure assessment. We use phthalates and bisphenol A-known industrial chemicals-and organophosphate insecticides as case studies to show exposure trends to these chemicals and their replacements (e.g., other phthalates, non-phthalate plasticizers, various bisphenols, pyrethroid insecticides) among the US general population. We compare US trends to national trends from Canada and Germany. Exposure to the original compounds is still prevalent among these general populations, but exposures to alternative chemicals may be increasing.