Modeling of heart excitation patterns caused by a local inhomogeneity
Modeling of heart excitation patterns caused by a local inhomogeneity
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DOI：
10.1006/jtbi.1996.0112
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发表时间：
1996-07-07
影响因子：
2
通讯作者：
Panfilov, AV
中科院分区：
文献类型：
--
作者：
Aliev, RR;Panfilov, AV
我们模拟波在整个心脏中的传播包含一个局部的不均匀性，其性质模仿的一些性质的心脏组织在急性期的梗死。心脏组织的动力学由FitzHugh-Nagumo（FHN）模型描述。我们发现，两个或几个短周期的心脏刺激导致发展的三维涡环，这是一个时间源的高频波。涡环位于梗死边界附近，并在心内膜和心外膜上产生多个局灶性波源。我们已经追踪了涡旋的细丝，并显示了它的动力学。以高频率连续刺激心脏导致文氏效应。(C)1996年学术出版社
We simulate wave propagation in the whole heart containing a local inhomogeneity whose properties mimic some properties of cardiac tissue during the acute phase of infarction. The dynamics of cardiac tissue is described by a FitzHugh-Nagumo (FHN) model. We show that two or several short-period stimulations of the heart lead to the development of a three-dimensional vortex ring, which is a temporal source of high frequency waves. The vortex ring is located near the boundary of the infarction and induces wave patterns which appear as several focal wave sources on the epicard and endocard. We have traced the filament of the vortex and show its dynamics. Continuous stimulation of the heart at high frequency resulted in the Wenckebach effect. (C) 1996 Academic Press Limited