T1 and T2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials
T1 and T2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials
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DOI：
10.1021/nn405977t
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发表时间：
2014-04-01
期刊：
影响因子：
17.1
通讯作者：
Cheon, Jinwoo
中科院分区：
文献类型：
--
作者：
Shin, Tae-Hyun;Choi, Jin-sil;Cheon, Jinwoo
生物医学成像技术的圣杯之一是实现对生物目标的精确成像。精密仪器的发展和造影剂的使用提高了生物医学成像的准确性。然而，虚假成像的问题仍然是一个问题。在这里，我们开发了一种双模伪影过滤纳米粒子显像剂(AFIA)，它由顺磁和超顺磁性纳米材料组合而成。该AFIA具有执行与逻辑门算法的能力，以消除原始图像中的虚假误差(伪影)，以提高MRI的准确性。我们证实了AFIA在MRI模体中的伪影过滤能力，并进一步证明了干细胞迁移的无伪影成像在体内是可能的。
One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.