Effects of reproductive hormones on experimental vaginal candidiasis
Effects of reproductive hormones on experimental vaginal candidiasis
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DOI：
10.1128/iai.68.2.651-657.2000
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发表时间：
2000-02-01
影响因子：
3.1
通讯作者：
Steele, C
中科院分区：
文献类型：
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作者：
Fidel, PL;Cutright, J;Steele, C
外阴阴道念珠菌病（VVC）是一种由白色念珠菌引起的机会性粘膜感染，影响大量健康的育龄妇女。WC的急性发作通常发生在妊娠期间和月经周期的黄体期，此时孕酮和雌激素水平升高。虽然雌激素依赖的实验啮齿动物模型的C。白色念珠菌阴道感染用于许多应用，生殖激素的作用和/或它们在获得阴道念珠菌病中的限制仍然不清楚。本研究探讨了雌激素和孕激素对实验性感染的几个方面以及相关的细胞介导的免疫反应的影响。结果表明，虽然降低雌激素浓度最终会影响感染诱导的阴道念珠菌滴度。白念珠菌和接种动物的感染率，在单独用各种浓度的孕酮处理的小鼠中不能实现实验感染。此外，孕酮对（i）雌激素存在下感染的诱导和持续性，（ii）原发性感染小鼠的迟发型超敏反应，或（iii）在假发情条件下对继发性阴道感染的部分保护没有影响。雌激素的其他结果表明，持续性感染可以建立与一个，可见范围的C。白念珠菌接种在超生理和接近生理（在发情期）浓度的雌激素和阴道真菌滴度或感染率是相似的，如果假发情开始前几天或接种后。然而，为了使感染持续，必须维持假发情状态。最后，发现雌激素降低了阴道上皮细胞抑制念珠菌生长的能力。白色念珠菌这些结果表明，雌激素，而不是孕激素，是一个重要的因素，在乳腺癌相关的易感性，以C。白色念珠菌阴道炎
Vulvovaginal candidiasis (VVC) is an opportunistic mucosal infection caused by Candida albicans that affects large numbers of otherwise healthy women of childbearing age. Acute episodes of WC often occur during pregnancy and during the luteal phase of the menstrual cycle, when levels of progesterone and estrogen are elevated. Although estrogen-dependent experimental rodent models of C. albicans vaginal infection are used for many applications, the role of reproductive hormones and/or their limits in the acquisition of vaginal candidiasis remain unclear. This study examined the effects of estrogen and progesterone on several aspects of an experimental infection together with relative cell-mediated immune responses. Results showed that while decreasing estrogen concentrations eventually influenced infection-induced vaginal titers of C. albicans and rates of infection in inoculated animals, the experimental infection could not be achieved in mice treated with various concentrations of progesterone alone. Furthermore, progesterone had no effect on (i) the induction and persistence of the infection in the presence of estrogen, (ii) delayed-type hypersensitivity in primary-infected mice, or (iii) the partial protection from a secondary vaginal infection under pseudoestrus conditions. Other results with estrogen showed that a persistent infection could be established with a,vide range of C. albicans inocula under supraphysiologic and near-physiologic (at estrus) concentrations of estrogen and that vaginal fungus titers or rates of infection were similar if pseudoestrus was initiated several days before or after inoculation. However, the pseudoestrus state had to be maintained for the infection to persist. Finally, estrogen was found to reduce the ability of vaginal epithelial cells to inhibit the growth of C. albicans. These results suggest that estrogen, but not progesterone, is an important factor in hormone-associated susceptibility to C. albicans vaginitis.