INHERENT CELLULAR RADIOSENSITIVITY AS A BASIC CONCEPT FOR HUMAN-TUMOR RADIOTHERAPY
INHERENT CELLULAR RADIOSENSITIVITY AS A BASIC CONCEPT FOR HUMAN-TUMOR RADIOTHERAPY
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DOI：
10.1016/0360-3016(81)90377-1
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发表时间：
1981-01-01
影响因子：
7
通讯作者：
MALAISE, EP
中科院分区：
文献类型：
--
作者：
FERTIL, B;MALAISE, EP
对59条已发表的人类细胞系存活曲线进行统计分析。6株来源于无遗传疾病患者的成纤维细胞系和36株肿瘤细胞系被使用。使用线性二次（L-Q）模型，它提供了一个全面充分的拟合，特别是在低剂量范围内，显示了细胞系之间的辐射敏感性存在很大的变化。在低剂量范围（.simeq）。2 Gy [Gray])，这些变化不能仅仅以技术因素为基础来解释。细胞类型被描述为固有的辐射敏感性因素，因为在低剂量下，细胞类型之间的平均辐射敏感性变化具有统计学意义。发现95%肿瘤控制剂量与给定细胞类型在2gy下的平均存活分数之间存在相关性。较高的放射敏感性伴随着较低的肿瘤控制剂量（TCD 95%）。这种相关性表明，某些肿瘤的中度放射可治愈性可以部分解释为相关肿瘤细胞的固有放射敏感性，特别是在2 Gy下的高存活率。
A statistical analysis was performed on a set of 59 published survival curves of human cell lines. Six fibroblast cell lines derived from patients free of genetic disorders and 36 tumor cell lines were used. Using the linear quadratic (L-Q) model, which provides an overall adequate fitting, especially in the low dose range, it was shown that great variations in radiosensitivity exist among cell lines. In the low dose range (.simeq. 2 Gy [Gray]), these variations cannot be explained on the mere basis of technical factors. Cell type is described as an intrinsic radiosensitivity factor, as variations of mean radiosensitivity among cell types are statistically significant at low doses. A correlation is found between the 95% tumor control dose and the mean surviving fraction at 2 Gy for a given cell type. Higher radiosensitivity is accompanied by lower tumor control dose (TCD 95%). This correlation suggests that the moderate radiocurability of certain tumors can be partially explained by the intrinsic radiosensitivity of relevant tumor cells and in particular by a high surviving fraction at 2 Gy.