Conditioned taste aversion and alcohol drinking: strain and gender differences.
Conditioned taste aversion and alcohol drinking: strain and gender differences.
复制标题
条件性味觉厌恶和饮酒：压力和性别差异。
DOI：
10.15288/jsa.2002.63.91
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
P. Mormède
中科院分区：
文献类型：
--
作者：
S. Cailhol;P. Mormède
目的
本研究探讨了乙醇诱导的条件性味觉厌恶（CTA）和乙醇口服自我管理（OSA）的雄性和雌性大鼠（N = 183）从三个相关的菌株没有遗传选择他们的乙醇偏好和不同的情绪反应谱之间的关系。使用的菌株是Wistar京都（WKY）、自发性高血压（SHR）和Wistar京都多动（WKHA）。我们假设，不同菌株对酒精厌恶性的敏感性差异可以解释不同的饮酒倾向。
方法
对所有动物进行三次预处理试验，包括20分钟接触糖精溶液，然后注射盐水或乙醇（0.5、1或1.5 g/kg，腹膜内）。动物随后自由接触乙醇OSA 3周，然后进行两次CTA试验。
结果
乙醇注射在所有动物中产生糖精消耗的剂量依赖性减少;此外，CTA的强度具有性别和品系依赖性。乙醇注射引起的味觉回避干扰了两种菌株（WKY和WKHA）的乙醇OSA的启动，但没有改变随后的长期乙醇消耗。此外，自愿饮酒的经验并不减弱乙醇诱导的CTA，乙醇诱导的CTA和乙醇OSA之间没有发现关联。
结论
这些数据证实了在饮酒和味觉厌恶学习中菌株之间和性别之间的巨大差异，但表明对酒精和饮酒的厌恶属性的敏感性之间没有关系。
OBJECTIVE
The present study examined the relationship between ethanol-induced conditioned taste aversion (CTA) and ethanol oral self-administration (OSA) in male and female rats (N = 183) from three related strains not genetically selected for their ethanol preference and differing in their emotional reactivity profile. The strains used were the Wistar Kyoto (WKY), Spontaneously Hypertensive (SHR) and Wistar Kyoto Hyperactive (WKHA). We hypothesized that differences between strains in sensitivity to the aversive properties of alcohol could explain the different propensities to drink alcohol solutions.
METHOD
All animals were given three conditioning trials consisting of 20-minute access to saccharin solution followed by saline or ethanol injections (0.5, 1 or 1.5 g/kg, intraperitoneally). Animals subsequently had free access to ethanol OSA for 3 weeks, followed by two CTA trials.
RESULTS
Ethanol injections produce a dose-dependent reduction of saccharin consumption in all animals; moreover, the strength of the CTA is gender- and strain-dependent. Taste avoidance induced by ethanol injections disturbed the initiation of ethanol OSA in two strains (WKY and WKHA) but did not change subsequent long-term ethanol consumption in either strain. In addition, voluntary alcohol drinking experience does not attenuate ethanol-induced CTA, and no association was found between ethanol-induced CTA and ethanol OSA.
CONCLUSIONS
The data confirm the large variation among strains and between genders in alcohol drinking and taste-aversion learning, but suggest that there is no relationship between the sensitivity to the aversive properties of alcohol and alcohol drinking.