Actin in membrane trafficking
Actin in membrane trafficking
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DOI：
10.1016/j.ceb.2007.04.017
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发表时间：
2007-08-01
影响因子：
7.5
通讯作者：
Lanzetti, Letizia
中科院分区：
文献类型：
--
作者：
Lanzetti, Letizia
肌动蛋白细胞骨架重塑提供了基于膜动力学的各种细胞过程所需的力，例如内吞作用、胞吐作用和高尔基体的囊泡运输。所有这些事件都由相关蛋白网络协调，其中一些与细胞迁移功能相关。与囊泡出芽和融合相关的肌动蛋白聚合的位点和持续时间受到小GTP酶和大GTP酶动力蛋白的严格控制。肌动蛋白聚合因子和内吞/外吞机制的结合研究，使肌动蛋白动力学与细胞表面膜运输的机制的理解取得了新的进展。
Actin cytoskeleton remodeling provides the forces required for a variety of cellular processes based on membrane dynamics, such as endocytosis, exocytosis, and vesicular trafficking at the Golgi. All these events are coordinated by networks of associated proteins, and some of them are functionally connected with cell migration, The site and the duration of actin polymerization, in connection with vesicle budding and fusion, are tightly controlled by both small GTPases and the large GTPase dynamin. Recent advances in the understanding of the mechanisms coupling actin dynamics with membrane trafficking at the cell surface have been brought by the combined studies of actin polymerizing factors and of the endocytic/exocytic machinery.