BIOMATERIAL-CENTERED SEPSIS AND THE TOTAL ARTIFICIAL-HEART - MICROBIAL ADHESION VS TISSUE INTEGRATION
BIOMATERIAL-CENTERED SEPSIS AND THE TOTAL ARTIFICIAL-HEART - MICROBIAL ADHESION VS TISSUE INTEGRATION
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DOI：
10.1001/jama.259.6.870
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发表时间：
1988-02-12
影响因子：
120.7
通讯作者：
DEVRIES, WC
中科院分区：
文献类型：
--
作者：
GRISTINA, AG;DOBBINS, JJ;DEVRIES, WC
全人工心脏扩展使用的主要障碍是感染，感染以构成假体装置的生物材料为中心，并因周围受损组织而加剧。从两名患者身上取出的全人工心脏的超微结构研究表明，真正的组织整合失败，生物材料表面的弥漫性、粘附性细菌定植失败。在某种程度上，生物材料容易受到感染，因为在目前的技术水平下，它们通常不能很好地与宿主组织结合，或者如果是血液动力学的，则不是最佳的生物相容性或抗粘附性。
The principal barrier to the extended use of the total artificial heart is infection that is centered on the biomaterial constituting the prosthetic device and exacerbated by the surrounding damaged tissue. Ultrastructural studies of total artificial hearts removed from two patients indicate a failure of true tissue integration and diffuse, adhesive bacterial colonization of biomaterial surfaces. Biomaterials are, in part, susceptible to infection because, at the present state of the art, they are usually not well integrated with host tissue, or if hemodynamic, not optimally biocompatible or antiadhesive.