Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides
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DOI：
10.1126/science.281.5382.1515
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发表时间：
1998-09-04
期刊：
影响因子：
56.9
通讯作者：
Poo, MM
中科院分区：
文献类型：
--
作者：
Song, HJ;Ming, GL;Poo, MM
神经生长受到神经系统中吸引和排斥因素的调节。 Collapsin-1/Semaphorin III/D (Sema III) 和髓磷脂相关糖蛋白的微观梯度通过培养的非洲爪蟾脊髓神经元的生长锥触发排斥性转向反应；通过分别药理激活鸟苷 3',5'-单磷酸 (cGMP) 和腺苷 3',5'-单磷酸信号通路，可以将排斥转化为吸引。 Sema ill 还会导致培养的大鼠感觉生长锥的崩溃，这可以通过 cGMP 途径的激活来抑制。因此，环核苷酸可以调节生长锥的行为，并且可以作为设计治疗的目标，以减轻排斥因素对神经再生的抑制。
Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured Xenopus spinal neurons; the repulsion can be converted to attraction by pharmacological activation of the guanosine 3',5'-monophosphate (cGMP) and adenosine 3',5'-monophosphate signaling pathways, respectively. Sema ill also causes the collapse of cultured rat sensory growth cones, which can be inhibited by activation of the cGMP pathway. Thus cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors.