Long-term outcomes of pediatric moyamoya disease treated by encephalo-duro-arterio-synangiosis
Long-term outcomes of pediatric moyamoya disease treated by encephalo-duro-arterio-synangiosis
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DOI：
10.1159/000048343
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发表时间：
2002-01-01
影响因子：
0.7
通讯作者：
Kobayashi, H
中科院分区：
文献类型：
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作者：
Isono, M;Ishii, K;Kobayashi, H
为了研究脑硬动脉联管术 (EDAS) 治疗儿童烟雾病的疗效，我们分析了 11 名随访超过 100 个月的患者。在 11 名患者的 22 侧中，我们对 10 名患者的 16 侧进行了 EDAS，对 4 名患者的 5 侧进行了脑硬动脉肌联结术 (EDAMS)，对 1 侧进行了脑肌联结术 (EMS)。 11 名患者中，8 名患者发育正常，无神经功能缺损。其余 3 名患者表现出轻度至中度神经功能缺损，但在这些病例中，术前和围术期损伤被认为是发病原因。在EDAS治疗的13侧中，有12侧观察到发育良好的新生血管形成。然而，在EMS或EDAMS治疗的6侧中，仅在3侧中观察到发育良好的新生血管形成。这些数据可能表明 EDAS 是小儿烟雾病手术治疗的一种替代治疗方法。版权所有 (C) 2002 S. Karger AG，巴塞尔。
To investigate the efficacy of encephalo-duro-arterio-synangiosis (EDAS) for the treatment of pediatric moya-moya disease, we analyzed 11 patients who were followed up for more than 100 months. Among 22 sides in 11 patients, we performed EDAS on 16 sides in 10 patients, encephalo-duro-arterio-myo-synangiosis (EDAMS) on 5 sides in 4 patients and encephalo-myo-synangiosis (EMS) on 1 side. Of the 11 patients, 8 patients showed normal development and had no neurological deficit. The remaining 3 patients showed mild to moderate neurological deficits, but in these cases, pre- and perioperative insults were considered to be attributable to the morbidities. Of 13 sides treated by EDAS, well-developed neovascularization was observed in 12. However, well-developed neovascularization was observed in only 3 out of 6 sides treated by EMS or EDAMS. These data might indicate that EDAS is a therapeutic alternative for the surgical treatment of pediatric moyamoya disease. Copyright (C) 2002 S. Karger AG, Basel.